Product image of Nadilaz (Azelastine Hydrochloride, Fluticasone Propionate) supplied by GNH India

Nadilaz

Active Ingredient:
Azelastine Hydrochloride, Fluticasone Propionate
Origin:
EU

Nadilaz (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine hydrochloride and fluticasone propionate, the active ingredients in Nadilaz, are an antihistamine and corticosteroid combination presented as a nasal spray for intranasal use. It treats allergic rhinitis and related nasal congestion in adults and children.

GNH India supplies Nadilaz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ace Pharmaceuticals Bv

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Indications & Clinical Uses

Nadilaz, a combination antihistamine and corticosteroid nasal spray, is used to manage allergic rhinitis and related nasal inflammation.

  • Seasonal allergic rhinitis: reduces sneezing, itching and nasal discharge during pollen seasons.
  • Perennial allergic rhinitis: controls year‑round symptoms caused by indoor allergens.
  • Nasal congestion due to allergic inflammation: decreases swelling of nasal passages and improves airflow.

How It Works

  • Azelastine hydrochloride blocks H1 histamine receptors, preventing histamine‑mediated itching, sneezing and rhinorrhea, while fluticasone propionate binds glucocorticoid receptors, suppressing inflammatory cytokine production and reducing mucosal edema in the nasal passages.

Side Effects

Nasal spray therapy may cause local and systemic reactions.

Common Side Effects

  • Nasal irritation or burning sensation
  • Headache
  • Bitter taste after administration
  • Epistaxis (nosebleed)
  • Throat irritation
  • Cough

Serious or Rare Side Effects

  • Nasal septal perforation
  • Severe allergic reaction (anaphylaxis)
  • Vision changes or increased intra‑ocular pressure
  • Adrenal suppression with prolonged use
  • Fungal sinusitis
  • Systemic corticosteroid effects such as hyperglycemia

Precautions & Warnings

Before using Nadilaz, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Nasal surgery or trauma: postpone use until the nasal mucosa has healed.
  • Use only as directed: avoid excessive dosing to reduce local irritation.
  • Known hypersensitivity: do not use if allergic to azelastine, fluticasone, or any excipients.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nadilaz may interact with other medicines; monitor the following.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase fluticasone exposure.
  • Live vaccines: systemic corticosteroid effect could reduce vaccine efficacy.
  • MAO inhibitors: may heighten hypertensive responses when combined with azelastine.

Moderate Interactions (Monitor Closely)

  • Oral antihistamines: additive sedative effect.
  • Beta‑blockers: may blunt response to epinephrine in anaphylaxis.
  • Ritonavir or other potent CYP3A4 inhibitors: may raise fluticasone levels.

Frequently Asked Questions

Nadilaz is indicated for the treatment of allergic rhinitis, both seasonal and perennial, and for relieving nasal congestion caused by allergic inflammation. It helps reduce sneezing, itching, runny nose, and nasal blockage in patients with these conditions.

Azelastine blocks H1 histamine receptors, preventing the immediate allergic response, while fluticasone binds glucocorticoid receptors to suppress inflammatory cytokines. Together they provide rapid symptom relief and reduce underlying nasal inflammation.

The specific dosing regimen for Nadilaz is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms, and clinical response. Patients should follow the prescriber’s instructions and the product label.

Safety data for Nadilaz in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the Nadilaz product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Nadilaz combines an antihistamine (azelastine) and a corticosteroid (fluticasone) in a single nasal spray, offering both rapid symptom relief and anti‑inflammatory action. Compared with single‑agent antihistamine sprays, it may provide greater control of congestion, while offering convenience over using two separate products.

Store Nadilaz at room temperature, below 25 °C, in its original packaging. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and do not freeze the product.

Nadilaz is administered as an intranasal spray. The patient should gently blow the nose, tilt the head slightly forward, insert the nozzle into each nostril, and spray the prescribed number of sprays while breathing in gently. The device should be primed according to the manufacturer’s instructions before first use.

Serious risks, though rare, include nasal septal perforation, severe allergic reactions such as anaphylaxis, vision changes or increased intra‑ocular pressure, adrenal suppression with prolonged use, and opportunistic fungal infections of the sinuses. Patients should seek immediate medical attention if any of these occur.

Nadilaz should be avoided by individuals with known hypersensitivity to azelastine, fluticasone, or any of the formulation’s excipients. It is also contraindicated in patients who have had recent nasal surgery or trauma until the nasal mucosa has healed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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