nafarelin acetate (Synarel) (SPRAY) 2 mg/mL

Nafarelin acetate (Synarel) 2 mg/mL nasal spray is a prescription hormone therapy used for conditions like endometriosis and uterine fibroids. This GnRH agonist helps regulate reproductive hormones when administered as directed. A convenient spray form for targeted delivery. Suitable for adults under medical supervision.

Strength

2 mg/mL

Manufacturer / TM Owner

G.D. Searle LLC Division of Pfizer Inc

Select Quantity

Pack/s

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Indications & Clinical Uses

Nafarelin acetate (Synarel) 2 mg/mL nasal spray is primarily used to manage endometriosis, a condition where tissue similar to the uterine lining grows outside the uterus. It may also help reduce symptoms of uterine fibroids, such as heavy menstrual bleeding and pelvic pain. This medication works by temporarily lowering hormone levels to ease symptoms. Always use as prescribed by a healthcare provider.

Side Effects

Nafarelin acetate (Synarel) 2 mg/mL nasal spray may cause temporary side effects like hot flashes, headaches, or changes in mood as the body adjusts to hormone adjustments. Nasal irritation or dryness can occur with regular use. These effects are generally mild and often resolve over time. Staying hydrated and using the spray as directed can help minimize discomfort.

Precautions & Warnings

Keep nafarelin acetate (Synarel) 2 mg/mL nasal spray refrigerated until use and store at room temperature once opened. Avoid exposing the spray to extreme heat or direct sunlight. Do not share this medication with others, even if they have similar symptoms. Consult a healthcare provider if you experience persistent nasal irritation or unusual side effects.

Avoid Interactions

Nafarelin acetate (Synarel) 2 mg/mL nasal spray may interact with other hormone-based medications, including birth control pills or estrogen supplements. Inform your healthcare provider about all medications, supplements, or herbal products you are using. Alcohol or certain over-the-counter products might also affect how this medication works. Always disclose your full medical history to avoid potential interactions.

Frequently Asked Questions

Use as directed by your healthcare provider, typically once or twice daily. Prime the pump before first use and follow the provided instructions for proper administration.

Common side effects may include hot flashes, headaches, mood changes, or nasal irritation. These are usually temporary and should be reported if persistent.

No, nafarelin acetate (Synarel) requires a prescription from a licensed healthcare provider for legal and safe use.

Symptom relief may take several weeks of consistent use. Follow your healthcare provider’s guidance for expected timelines.

Nafarelin acetate (Synarel) is not recommended during pregnancy. Discuss family planning with your healthcare provider before starting this medication.

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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical wholesaler & exporter

Last updated: 17 Jun 2026

References

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