Product image of Nafloxin (Ciprofloxacin Hydrochloride) supplied by GNH India

Nafloxin

Active Ingredient:
Ciprofloxacin Hydrochloride
Origin:
EU

Nafloxin (Ciprofloxacin Hydrochloride)

Ciprofloxacin Hydrochloride, the active ingredient in Nafloxin, is a fluoroquinolone antibiotic presented as an ophthalmic preparation for ocular use. It treats bacterial conjunctivitis, keratitis and other ocular bacterial infections in patients requiring topical therapy.

GNH India supplies Nafloxin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cooper Pharmaceuticals S.A.

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Indications & Clinical Uses

Nafloxin is a fluoroquinolone antibiotic used to manage bacterial infections of the eye and related structures.

  • Bacterial conjunctivitis: reduces bacterial load and accelerates resolution of redness and discharge.
  • Keratitis: eradicates causative bacteria, promoting corneal healing and visual recovery.
  • Other ocular bacterial infections: treats infections such as blepharitis or postoperative bacterial inflammation, helping to prevent complications.

How It Works

  • Ciprofloxacin Hydrochloride inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By blocking these targets, the drug prevents bacterial cell division and leads to bacterial cell death, providing a bactericidal effect against susceptible ocular pathogens.

Side Effects

Adverse reactions may occur with any ophthalmic antibiotic. Most are mild and resolve after discontinuation.

Common Side Effects

  • Stinging or burning sensation upon instillation.
  • Redness of the conjunctiva.
  • Temporary blurred vision.
  • Eyelid edema or itching.
  • Mild ocular irritation.

Serious or Rare Side Effects

  • Allergic contact dermatitis or severe hypersensitivity.
  • Corneal ulceration or perforation.
  • Tendon rupture (systemic exposure).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Vision loss due to severe ocular inflammation.

Precautions & Warnings

Before prescribing Nafloxin, clinicians should consider patient‑specific factors and safety measures.

  • Allergy assessment: verify no known hypersensitivity to fluoroquinolones or ophthalmic excipients.
  • Infection type: avoid use for viral, fungal or allergic conjunctivitis.
  • Corneal integrity: use with caution in patients with epithelial defects or recent corneal surgery.
  • Concomitant steroids: monitor closely as steroids may delay wound healing.
  • Contact lens wear: advise removal of lenses during treatment.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Ciprofloxacin ophthalmic solutions can interact with systemic or ocular agents, influencing safety or efficacy.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: cumulative toxicity, especially tendon or CNS effects.
  • Oral antacids or supplements containing magnesium/aluminum: may increase systemic exposure if absorbed.
  • Warfarin: potential enhancement of anticoagulant effect.
  • Corticosteroid eye drops: increased risk of delayed corneal healing.

Moderate Interactions (Monitor Closely)

  • Other topical antibiotics: possible antagonism or reduced efficacy.
  • Non‑steroidal anti‑inflammatory eye drops: monitor for ocular irritation.
  • Tetracycline eye ointments: assess for additive photosensitivity.
  • Systemic NSAIDs: watch for tendon‑related adverse events.

Frequently Asked Questions

Nafloxin is an ophthalmic formulation of ciprofloxacin hydrochloride indicated for the treatment of bacterial eye infections such as bacterial conjunctivitis, keratitis, and other ocular bacterial conditions. It works by eliminating susceptible bacteria, helping to reduce inflammation, discharge, and prevent complications that could affect vision.

Ciprofloxacin hydrochloride inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By blocking these targets, the drug prevents bacterial cell division, leading to a bactericidal effect that clears the infection in the eye.

The dosing regimen for Nafloxin is determined by the prescribing clinician based on the severity of the infection, patient age, and response to therapy. The prescriber will specify the number of drops, frequency, and duration appropriate for each individual case.

The safety of Nafloxin (ciprofloxacin hydrochloride) in pregnancy or while breastfeeding has not been definitively established. Healthcare providers should weigh the potential benefits against possible risks and consider alternative treatments when safer options are available.

To order Nafloxin, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Nafloxin (ciprofloxacin) belongs to the fluoroquinolone class, offering broad‑spectrum coverage against Gram‑negative and some Gram‑positive ocular pathogens. Compared with older agents such as chloramphenicol or sulfonamides, ciprofloxacin generally provides faster bacterial eradication and a lower risk of resistance, though local susceptibility patterns should guide selection.

Nafloxin should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and discard any solution that appears discolored or contains particles.

Nafloxin is applied topically to the eye as directed by the prescriber. Typically, a few drops are placed in the affected eye(s) at the prescribed frequency, ensuring the eyelids are gently closed for a short period to allow adequate absorption.

Serious risks, though rare, include severe allergic reactions such as Stevens‑Johnson syndrome, corneal ulceration or perforation, and systemic tendon rupture. Patients should seek immediate medical attention if they experience intense pain, vision changes, swelling, or signs of a severe hypersensitivity reaction.

Nafloxin should not be used by individuals with a known hypersensitivity to ciprofloxacin, other fluoroquinolones, or any component of the ophthalmic formulation. It is also contraindicated for viral, fungal, or allergic eye conditions where an antibacterial agent would be ineffective.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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