Product image of Naftifina Atb (Naftifine Hydrochloride) supplied by GNH India

Naftifina Atb

Active Ingredient:
Naftifine Hydrochloride
Origin:
EU

Naftifina Atb (Naftifine Hydrochloride)

Naftifine Hydrochloride, the active ingredient in Naftifina Atb, is an allylamine antifungal presented as a topical formulation for skin application. It is used to treat superficial fungal infections, including athlete’s foot, ringworm, jock itch and tinea versicolor, in both adult and pediatric patients.

GNH India supplies Naftifina Atb as a licensed, GDP‑compliant international pharmaceutical supplier, sourcing the product from EU‑regulated manufacturers and delivering to hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Antibiotice Sa

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Indications & Clinical Uses

Naftifine Hydrochloride is applied topically to treat fungal skin infections within the dermatophyte and yeast disease family.

  • Tinea pedis: Reduces itching, scaling and erythema associated with athlete’s foot.
  • Tinea corporis: Clears ring‑shaped lesions and prevents spread of infection.
  • Tinea cruris: Relieves inflammation and resolves jock itch symptoms.
  • Tinea versicolor: Improves discoloration and normalizes skin pigmentation.
  • Superficial dermatophyte infections: Eradicates fungal growth on the skin surface.

How It Works

  • Naftifine Hydrochloride inhibits the fungal enzyme squalene epoxidase, blocking the conversion of squalene to ergosterol. This depletes ergosterol, a key component of fungal cell membranes, and causes accumulation of toxic squalene, leading to increased membrane permeability and fungal cell death. The selective inhibition disrupts fungal membranes without affecting human cells, providing targeted antifungal activity.

Side Effects

Topical application of Naftifine Hydrochloride may be associated with local skin reactions.

Common Side Effects

  • Itching: mild to moderate sensation at the application site.
  • Burning: transient heat sensation after application.
  • Stinging: brief sharp discomfort.
  • Redness: localized erythema.
  • Dry skin: mild desiccation of treated area.
  • Contact dermatitis: mild allergic skin reaction.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Extensive skin irritation: intense redness or swelling beyond the treated area.
  • Angioedema: rapid swelling of lips, tongue or face.
  • Anaphylaxis: life‑threatening systemic allergic response.
  • Stevens‑Johnson syndrome: rare severe skin disorder.
  • Toxic epidermal necrolysis: extremely rare, severe skin detachment.

Precautions & Warnings

Before using Naftifine Hydrochloride, consider the following safety measures.

  • Avoid use on broken skin: limit application to intact epidermis.
  • Do not apply to mucous membranes: keep product away from eyes, mouth and genital mucosa.
  • Discontinue if severe irritation occurs: stop treatment and seek medical advice.
  • Consult a healthcare professional before use in children under 2 years: pediatric safety not fully established.
  • Avoid concurrent use with other topical irritants or corticosteroids unless directed: may increase risk of irritation or reduce efficacy.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Naftifine Hydrochloride has a limited interaction profile, but certain combinations may affect safety or efficacy.

Major Interactions (Avoid)

  • Concurrent use with other topical antifungal agents: may increase local irritation.
  • Application over skin treated with chemical peels or abrasive agents: heightened risk of dermatitis.

Moderate Interactions (Monitor Closely)

  • Co‑application with topical corticosteroids: may diminish antifungal effectiveness.
  • Use with skin products containing alcohol, fragrances or harsh preservatives: can exacerbate local irritation.
  • Simultaneous use of systemic antifungals that affect CYP450 enzymes: monitor for systemic side‑effects, although topical absorption is minimal.

Frequently Asked Questions

Naftifina Atb is a topical antifungal indicated for superficial fungal skin infections such as athlete’s foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris), tinea versicolor and other dermatophyte infections affecting the skin surface.

The active ingredient, Naftifine Hydrochloride, blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. This leads to accumulation of toxic squalene, disruption of membrane integrity and ultimately fungal cell death.

The dosing regimen for Naftifina Atb is determined by the prescribing healthcare professional. Typically, a thin layer is applied to the affected skin once or twice daily, but the exact frequency and duration depend on the severity of the infection and the prescriber’s judgment.

Safety data for Naftifine Hydrochloride in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Naftifine Hydrochloride belongs to the allylamine class, offering a rapid fungicidal effect similar to terbinafine but with a broader spectrum that includes certain yeasts causing tinea versicolor. Compared with azole antifungals, allylamines generally have fewer drug‑interaction concerns and a lower risk of resistance development.

Store Naftifina Atb at temperatures below 25 °C in its original packaging. Protect the product from moisture, direct sunlight and extreme temperature fluctuations to maintain its stability and efficacy.

Clean and dry the affected skin area before use. Apply a thin layer of the cream or solution to the lesion and gently rub it in. Wash hands after application unless the hands are the treatment site. Follow the prescriber’s instructions regarding frequency and duration of therapy.

Although rare, serious adverse reactions can include severe allergic responses such as anaphylaxis, extensive skin irritation, angioedema, Stevens‑Johnson syndrome or toxic epidermal necrolysis. Immediate medical attention is required if any of these symptoms develop.

Individuals with a known hypersensitivity to Naftifine Hydrochloride or any component of the formulation should avoid its use. It is also contraindicated on broken or severely inflamed skin, and caution is advised for young children unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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