Naklofen (Diclofenac Sodium)

Diclofenac Sodium works by reversibly inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the production of prostaglandins. Lower prostaglandin levels diminish pain signaling, fever, and inflammation, leading to decreased swelling and improved comfort at the affected site.

The specific dose and frequency of Naklofen are determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and overall health status. Healthcare professionals follow local prescribing guidelines and adjust the regimen as needed.

Safety data for diclofenac sodium during pregnancy and lactation are limited, and the product is generally classified as contraindicated or to be used only if the potential benefit justifies the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Naklofen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Naklofen, as an injectable formulation of diclofenac, offers rapid systemic exposure compared with oral NSAIDs, which can be advantageous for acute postoperative pain. Its COX inhibition profile is similar to other non‑selective NSAIDs, but the intramuscular route may provide quicker onset while still sharing the same safety considerations regarding gastrointestinal, renal and cardiovascular effects.

Naklofen must be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. If the product reaches room temperature for a short period, it may be used, but it should be returned to refrigeration promptly.

Naklofen is administered by a qualified healthcare professional as an intramuscular injection. The injection site is typically a large muscle such as the gluteus maximus or deltoid. Proper aseptic technique and dosage calculation by the prescriber are essential to ensure safety and efficacy.

Serious adverse reactions include severe gastrointestinal bleeding or ulceration, hepatotoxicity (elevated liver enzymes or hepatitis), anaphylactic shock, and cardiovascular events such as myocardial infarction or stroke. Patients should be monitored for signs of these conditions, and treatment should be stopped immediately if they occur.

Naklofen is contraindicated in patients with known hypersensitivity to diclofenac or other NSAIDs, those with active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and individuals who have experienced a recent myocardial infarction or uncontrolled hypertension. Use should also be avoided in pregnancy unless clearly justified.