Naklofen (Diclofenac Sodium)

Diclofenac sodium works by reversibly inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the synthesis of prostaglandins that mediate pain, fever, and inflammation. Lower prostaglandin levels diminish peripheral sensitisation of nerve endings and limit the inflammatory response.

The specific dose and frequency of Naklofen are determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and individual risk factors. Healthcare professionals should follow local prescribing guidelines and adjust the regimen as needed.

Safety data for diclofenac sodium in pregnancy and lactation are limited. It is generally advised to avoid routine use during the first trimester and to consider alternative therapies. Breastfeeding mothers should consult a healthcare provider, as diclofenac may be excreted in milk.

To request Naklofen, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where applicable) and necessary import documentation.

Both Naklofen (diclofenac) and ibuprofen belong to the NSAID class, but diclofenac is often considered more potent on a milligram‑per‑milligram basis for inflammatory pain. Diclofenac may have a higher risk of cardiovascular and gastrointestinal adverse events, so clinicians weigh efficacy against safety when choosing between them.

Naklofen should be stored at ambient temperature, protected from light and moisture, and kept in its original packaging until use. The product should not be frozen. Follow standard aseptic techniques when preparing the intramuscular injection to maintain sterility.

Naklofen is supplied as a sterile injectable solution for intramuscular injection. The healthcare professional selects an appropriate muscle site, typically the gluteal or deltoid region, and administers the dose using a sterile needle and syringe according to standard intramuscular injection procedures.

Serious risks include gastrointestinal ulceration or bleeding, severe skin reactions such as Stevens‑Johnson syndrome, acute renal impairment, hepatotoxicity, and increased risk of cardiovascular events like myocardial infarction or stroke. Patients should be monitored for signs of these conditions, especially if they have pre‑existing risk factors.

Naklofen is contraindicated in patients with known hypersensitivity to diclofenac or other NSAIDs, active gastrointestinal ulceration or bleeding, severe heart failure, and those who have had a recent coronary artery bypass graft. Caution is also advised for patients with impaired renal or hepatic function, and it should be avoided in pregnancy unless clearly indicated.