Product image of Nalador 500 (Sulprostone) supplied by GNH India

Nalador 500

Active Ingredient:
Sulprostone
Origin:
EU

Nalador 500 (Sulprostone)

Sulprostone, the active ingredient in Nalador 500, is a prostaglandin E2 analog presented as an injectable solution for intravenous use. It is employed to stimulate uterine contractility for labor induction, to manage postpartum hemorrhage, and to aid in the prevention of recurrent gastric ulcers.

GNH India supplies Nalador 500 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide, adhering to stringent quality standards and providing reliable logistics for global distribution.

Manufacturer / TM Owner

Teofarma S.R.L.

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Indications & Clinical Uses

Sulprostone is used in obstetric and gastrointestinal settings where prostaglandin‑mediated uterine activity or gastric protection is required.

  • Induction of labor: facilitates cervical ripening and uterine contractions to initiate delivery.
  • Management of postpartum hemorrhage: enhances uterine tone to reduce bleeding after childbirth.
  • Prevention of gastric ulcer recurrence: promotes mucosal protection and reduces ulcer re‑formation.

How It Works

  • Sulprostone acts as an agonist at prostaglandin E2 (EP) receptors, especially EP1 and EP3, on smooth‑muscle cells of the uterus and gastric mucosa. Receptor activation raises intracellular calcium, producing stronger uterine contractions and increased tone. In the gastrointestinal tract, EP stimulation enhances mucus and bicarbonate secretion, supporting mucosal defense and limiting ulcer formation.

Side Effects

Sulprostone may be associated with a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea: mild to moderate feeling of sickness.
  • Vomiting: occasional episodes.
  • Diarrhea: loose stools.
  • Flushing: transient skin redness.

Serious or Rare Side Effects

  • Severe uterine hyperstimulation: excessive contractions that may compromise fetal oxygenation.
  • Pulmonary edema: fluid accumulation in the lungs requiring medical attention.
  • Anaphylactic reaction: rapid onset of allergic symptoms such as airway swelling and hypotension.

Precautions & Warnings

When using Nalador 500, clinicians should observe several safety measures.

  • Contraindication in known hypersensitivity: avoid use in patients with documented allergy to sulprostone or related prostaglandins.
  • Caution in cardiovascular disease: monitor for hypertension or arrhythmias during infusion.
  • Use with care in asthma: prostaglandins may provoke bronchospasm.
  • Avoid in active labor with fetal distress: excessive uterine activity can worsen fetal condition.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sulprostone can interact with other medicines, requiring attention to potential effects.

Major Interactions (Avoid)

  • Concurrent use with other uterotonics (e.g., oxytocin, misoprostol): may cause dangerous uterine hyperstimulation.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): can diminish prostaglandin efficacy and increase bleeding risk.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: sulprostone may counteract blood pressure control; monitor hemodynamics.
  • Diuretics: potential for fluid imbalance when pulmonary edema risk is present.
  • Anticoagulants: increased bleeding tendency during postpartum hemorrhage management; observe coagulation parameters.

Frequently Asked Questions

Nalador 500 contains sulprostone and is used to induce labor, control postpartum hemorrhage by strengthening uterine contractions, and to help prevent the recurrence of gastric ulcers through mucosal protection.

Sulprostone binds to prostaglandin E2 (EP) receptors, mainly EP1 and EP3, on uterine smooth muscle and gastric mucosa. This activation raises intracellular calcium, causing stronger uterine contractions and increased gastric mucus secretion, which together support labor induction and ulcer prevention.

The dose of Nalador 500 is determined by the prescribing clinician based on the specific indication, patient condition, and clinical guidelines. Healthcare professionals adjust the amount and infusion rate to achieve the desired therapeutic effect.

Sulprostone is intended for use in pregnant women when labor induction or hemorrhage control is required, but it should only be administered under close medical supervision. Limited data are available for breastfeeding, so clinicians weigh potential risks and benefits before use.

To order Nalador 500, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Sulprostone is a prostaglandin E2 analog, offering a rapid onset of uterine contraction similar to oxytocin but with a distinct receptor profile. Unlike misoprostol, it is administered intravenously, allowing precise dose control. Choice of agent depends on clinical scenario, patient tolerance and institutional protocols.

Nalador 500 must be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the vial. Before use, allow the solution to reach room temperature if required, and inspect for particulate matter or discoloration.

Nalador 500 is given as an intravenous injection or infusion under the direction of a qualified healthcare professional. The administration rate and total volume are set by the prescriber, and the patient is monitored for uterine response and any adverse reactions during and after the infusion.

Serious risks include severe uterine hyperstimulation, which can compromise fetal oxygenation, pulmonary edema, and anaphylactic reactions. Prompt recognition of excessive contractions, respiratory distress, or allergic signs is essential, and immediate medical intervention should be initiated if they occur.

Nalador 500 should be avoided in patients with known hypersensitivity to sulprostone or related prostaglandins, in individuals with uncontrolled cardiovascular disease, severe asthma, or in cases of fetal distress where excessive uterine activity could be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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