Product image of Nalapres (Lisinopril Dihydrate, Hydrochlorothiazide) supplied by GNH India

Nalapres

Active Ingredient:
Lisinopril Dihydrate, Hydrochlorothiazide
Origin:
EU

Nalapres (Lisinopril Dihydrate, Hydrochlorothiazide)

Lisinopril Dihydrate, the active ingredient in Nalapres, is an ACE inhibitor presented as an oral tablet for systemic administration. It is formulated together with Hydrochlorothiazide, a thiazide diuretic, to create a fixed‑dose combination that lowers blood pressure in adult patients with hypertension. The product conforms to European Union quality standards.

GNH India supplies Nalapres as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to EU‑origin antihypertensive medicines and supporting regulatory compliance for each market.

Manufacturer / TM Owner

Neopharmed Gentili Spa

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nalapres is indicated for hypertension, acting on the renin‑angiotensin system and renal sodium handling to achieve blood‑pressure control.

  • Hypertension: lowers systolic and diastolic blood pressure in adults.
  • Resistant hypertension: adds diuretic effect when an ACE inhibitor alone is insufficient.
  • Hypertension with fluid retention: combines vasodilation and natriuresis to improve overall control.

How It Works

  • Lisinopril Dihydrate inhibits angiotensin‑converting enzyme, reducing formation of angiotensin II and decreasing vasoconstriction and aldosterone release. Hydrochlorothiazide blocks Na⁺/Cl⁻ reabsorption in the distal convoluted tubule, increasing sodium and water excretion. The combined actions reduce vascular resistance and plasma volume, resulting in lowered arterial pressure.

Side Effects

Nalapres may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Cough: dry, persistent throat irritation.
  • Dizziness or light‑headedness, especially after standing.
  • Headache: mild to moderate intensity.
  • Increased urination: due to diuretic effect.
  • Electrolyte disturbances: mild hypokalemia or hyponatremia.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or airway.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Acute renal impairment: sudden decrease in kidney function.
  • Hyperkalemia: elevated potassium levels, potentially dangerous.

Precautions & Warnings

Before prescribing Nalapres, clinicians should consider several safety measures.

  • Monitor blood pressure: ensure adequate control without excessive drop.
  • Assess renal function: check serum creatinine and eGFR regularly.
  • Check electrolytes: watch for potassium and sodium abnormalities.
  • Avoid use in pregnancy: potential fetal harm; contraindicated.
  • Caution with NSAIDs or lithium: may increase risk of renal dysfunction or toxicity.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nalapres can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Concomitant use with aliskiren in diabetic patients: risk of renal impairment and hyperkalemia.
  • Potassium‑sparing diuretics or supplements: may cause dangerous hyperkalemia.
  • Lithium therapy: thiazide component can raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect and affect kidney function.
  • Other antihypertensives (beta‑blockers, calcium channel blockers): may increase risk of hypotension.
  • Antidiabetic agents: ACE inhibition can enhance hypoglycemic response.

Frequently Asked Questions

Nalapres is a fixed‑dose oral combination of lisinopril dihydrate and hydrochlorothiazide that is prescribed to lower elevated blood pressure in adult patients with hypertension, especially when a single‑agent therapy does not provide adequate control.

Lisinopril dihydrate blocks the angiotensin‑converting enzyme, which reduces the production of angiotensin II, a potent vasoconstrictor. This leads to relaxed blood vessels, decreased aldosterone release, and ultimately lower arterial pressure.

The specific dose of Nalapres is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any relevant laboratory values. Patients should follow the prescriber’s instructions exactly.

Lisinopril, an ACE inhibitor, is generally contraindicated in pregnancy because of potential fetal toxicity. Safety during breastfeeding has not been established, and the prescriber should evaluate risks versus benefits before use in these populations.

To request Nalapres, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nalapres combines an ACE inhibitor with a thiazide diuretic, offering both vasodilation and diuretic‑induced fluid loss. This dual mechanism can achieve better blood‑pressure control than monotherapy with either class alone, and it simplifies dosing compared with taking two separate tablets.

Store Nalapres at room temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Nalapres is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.

Serious risks include angioedema (swelling of the face, lips, tongue, or airway), severe hypotension, acute renal impairment, and hyperkalemia. Patients should seek immediate medical attention if they experience any signs of these conditions.

Nalapres should be avoided in patients with known hypersensitivity to lisinopril, hydrochlorothiazide, or any component of the formulation, in those with a history of angioedema related to ACE inhibitors, and in pregnancy. Caution is also advised for individuals with severe renal impairment or electrolyte disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Lisinopril Dihydrate, Hydrochlorothiazide

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT