Product image of Nalcrom (Sodium Cromoglicate) supplied by GNH India

Nalcrom

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Nalcrom (Sodium Cromoglicate)

Sodium cromoglicate, the active ingredient in Nalcrom, is a mast cell stabilizer presented as an oral dosage form for oral use. It is used to prevent symptoms of allergic rhinitis, allergic conjunctivitis, food allergy and asthma in patients requiring prophylactic therapy.
GNH India supplies Nalcrom as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hormosan Pharma Gmbh

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Indications & Clinical Uses

  • Nalcrom is a mast cell stabilizer indicated for several allergic and respiratory conditions.
  • Allergic rhinitis: reduces nasal congestion, sneezing and itching caused by allergen exposure.
  • Allergic conjunctivitis: alleviates eye redness, itching and tearing associated with allergic triggers.
  • Food allergy: helps prevent systemic allergic reactions after ingestion of known allergens.
  • Asthma prophylaxis: decreases frequency of bronchospasm episodes when used as part of a maintenance regimen.

How It Works

  • Sodium cromoglicate stabilizes mast cells by inhibiting calcium‑dependent degranulation, which prevents the release of histamine, leukotrienes and other inflammatory mediators. By blocking this cascade, it reduces the immediate hypersensitivity response in the respiratory and ocular mucosa and limits systemic allergic reactions.

Side Effects

Adverse reactions may occur with oral sodium cromoglicate therapy.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Abdominal pain: occasional cramping or discomfort.
  • Diarrhea: loose stools, usually transient.
  • Headache: mild tension‑type headache.
  • Taste alteration: temporary metallic or bitter taste.
  • Flatulence: increased intestinal gas.

Serious or Rare Side Effects

  • Anaphylaxis: rare severe allergic reaction requiring immediate medical attention.
  • Severe rash: including Stevens‑Johnson syndrome.
  • Eosinophilic colitis: inflammation of the colon with eosinophil infiltration.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Severe bronchospasm: paradoxical worsening of asthma symptoms.
  • Angioedema: swelling of face, lips or tongue.

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Pregnancy: consult a healthcare professional to weigh potential risks and benefits.
  • Breastfeeding: discuss possible effects on the infant with a physician.
  • Renal impairment: monitor renal function and adjust therapy if needed.
  • Concomitant medications: review all current drugs for possible interactions.
  • Pediatric use: use with caution in children; dosing is age‑dependent.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Sodium cromoglicate may interact with other medications; monitor as indicated.

Major Interactions (Avoid)

  • Systemic corticosteroids: may mask symptom progression, requiring close supervision.
  • Immunosuppressants: concurrent use can alter immune response, necessitating physician oversight.

Moderate Interactions (Monitor Closely)

  • Antihistamines: additive effect on symptom control, adjust dosing if needed.
  • Theophylline: possible alteration of plasma levels; monitor therapeutic range.
  • NSAIDs: increased risk of gastrointestinal irritation.
  • ACE inhibitors: monitor for persistent cough or angioedema.
  • Beta‑agonists: watch for additive bronchodilator effects.

Frequently Asked Questions

Nalcrom, containing sodium cromoglicate, is prescribed to prevent symptoms of allergic rhinitis, allergic conjunctivitis, food‑induced allergic reactions and to provide prophylaxis for asthma. It works by stabilizing mast cells, thereby reducing the release of histamine and other mediators that trigger allergic responses.

Sodium cromoglicate binds to mast cells and blocks calcium‑dependent degranulation. This inhibition prevents the release of histamine, leukotrienes and other inflammatory substances that cause the immediate symptoms of allergy and asthma, helping to maintain normal airway and ocular function.

The dosage of Nalcrom is individualized by the prescribing clinician based on the patient’s age, weight, severity of symptoms and specific indication. Only a qualified healthcare professional should determine the appropriate dose and dosing schedule.

Safety data for sodium cromoglicate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting Nalcrom.

To request Nalcrom, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike antihistamines that block histamine receptors after release, Nalcrom stabilizes mast cells to prevent mediator release in the first place. This upstream action can be advantageous for patients who need prophylactic control without sedation, but it may be used in combination with antihistamines for broader symptom coverage.

Nalcrom should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Nalcrom is taken orally, usually as a tablet or capsule, with or without food as directed by the prescriber. The exact method of administration, including timing relative to meals, should follow the healthcare professional’s instructions.

Although rare, serious adverse reactions can include anaphylaxis, severe skin rashes such as Stevens‑Johnson syndrome, eosinophilic colitis, hepatic dysfunction, severe bronchospasm and angioedema. Patients should seek immediate medical attention if any of these symptoms develop.

Nalcrom is contraindicated in individuals with known hypersensitivity to sodium cromoglicate or any of the product’s excipients. Patients with a history of severe allergic reactions to mast cell stabilizers should avoid use and discuss alternatives with their clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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