Product image of Nalgesic (Fenoprofen Calcium) supplied by GNH India

Nalgesic

Active Ingredient:
Fenoprofen Calcium
Origin:
EU

Nalgesic (Fenoprofen Calcium)

Fenoprofen calcium, the active ingredient in Nalgesic, is a nonsteroidal anti-inflammatory drug presented as an oral formulation for systemic use. It is used to relieve mild to moderate pain and to reduce inflammation in conditions such as rheumatoid arthritis and osteoarthritis.

GNH India supplies Nalgesic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Sciencex

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Indications & Clinical Uses

Nalgesic (fenoprofen calcium) is employed in the management of inflammatory and musculoskeletal disorders.

  • Mild to moderate pain: provides analgesic relief by reducing prostaglandin‑mediated nociception.
  • Rheumatoid arthritis: decreases joint inflammation, swelling and stiffness.
  • Osteoarthritis: alleviates chronic joint pain and improves functional mobility.

How It Works

  • Fenoprofen calcium exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes inflammation, pain signaling, and fever responses in affected tissues.

Side Effects

Adverse reactions may occur with any NSAID, including fenoprofen calcium.

Common Side Effects

  • Gastrointestinal discomfort: dyspepsia, nausea, or abdominal pain.
  • Headache or dizziness.
  • Skin rash or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment or acute kidney injury.
  • Hepatic dysfunction, including elevated transaminases.
  • Severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome.
  • Cardiovascular events, including thrombotic complications.

Precautions & Warnings

Before prescribing fenoprofen calcium, clinicians should consider several safety measures.

  • Assess renal function: evaluate baseline creatinine and eGFR.
  • Monitor gastrointestinal risk: avoid use in patients with a history of ulcer disease or bleeding.
  • Use with caution in cardiovascular disease: consider alternative NSAIDs if high thrombotic risk.
  • Avoid concomitant anticoagulants unless necessary: increased bleeding potential.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Fenoprofen calcium may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Selective COX‑2 inhibitors: additive renal toxicity.
  • Lithium: increased serum lithium concentrations.
  • Methotrexate: reduced renal clearance leading to toxicity.
  • ACE inhibitors or ARBs: potential for acute renal impairment.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in renal perfusion.
  • Corticosteroids: increased risk of gastrointestinal ulceration.
  • SSRIs or SNRIs: modest increase in bleeding tendency.

Frequently Asked Questions

Nalgesic, containing fenoprofen calcium, is prescribed to treat mild to moderate pain and to manage inflammatory conditions such as rheumatoid arthritis and osteoarthritis. It helps reduce swelling, stiffness, and discomfort associated with these disorders.

Fenoprofen calcium works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. Lower prostaglandin levels lead to reduced inflammation, pain signaling, and fever responses in the affected tissues.

The specific dose of Nalgesic is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for fenoprofen calcium in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Fenoprofen calcium has a similar mechanism to other non‑selective NSAIDs such as ibuprofen, but it may offer a longer half‑life and different potency for certain inflammatory conditions. Choice of NSAID depends on individual patient response, safety profile, and physician preference.

Nalgesic should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and heat sources to maintain its stability and potency.

Nalgesic is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with food may reduce gastrointestinal discomfort. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include gastrointestinal ulceration or bleeding, renal impairment, hepatic dysfunction, severe hypersensitivity reactions such as anaphylaxis, and increased cardiovascular events. Patients should be monitored for these adverse effects, especially during long‑term therapy.

Nalgesic should be avoided in individuals with known hypersensitivity to fenoprofen or other NSAIDs, active gastrointestinal ulceration, severe renal or hepatic impairment, and in patients taking anticoagulants where bleeding risk is unacceptable, unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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