Nalgesin (Naproxen Sodium)

Nalgesin (naproxen sodium) acts on inflammatory pathways to provide analgesic and antipyretic effects.

• Mild to moderate pain: alleviates headache, dental pain, and postoperative discomfort.
• Osteoarthritis: reduces joint swelling and improves mobility.
• Rheumatoid arthritis: helps control chronic inflammation and pain.
• Musculoskeletal pain: eases strain, sprain, and backache symptoms.
• Dysmenorrhea: lessens menstrual cramps and associated discomfort.
• Fever: lowers elevated body temperature in acute febrile states.

• Naproxen sodium non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at peripheral and central sites.

Adverse reactions may vary in frequency and severity.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia, or abdominal pain.
• Headache or dizziness.
• Mild skin rash or itching.
• Diarrhea or constipation.
• Elevated blood pressure in some patients.

Serious or Rare Side Effects

• Gastrointestinal bleeding, ulceration, or perforation.
• Cardiovascular events such as myocardial infarction or stroke.
• Acute renal impairment or worsening of chronic kidney disease.
• Severe skin reactions (e.g., Stevens‑Johnson syndrome).
• Hepatic dysfunction with elevated liver enzymes.
• Anaphylaxis or severe hypersensitivity reactions.

When prescribing Nalgesin, clinicians should consider individual risk factors and monitor for complications.

• Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
• Evaluate cardiovascular profile: use caution in those with heart disease or hypertension.
• Monitor renal function: adjust use in patients with impaired kidney function.
• Use the lowest effective dose for the shortest duration needed.
• Avoid in individuals with known hypersensitivity to naproxen or other NSAIDs.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Naproxen sodium can alter the effects of several co‑administered medicines.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): amplified bleeding tendency.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.

• Diuretics: may diminish diuretic efficacy and affect kidney function.
• Lithium: naproxen can raise lithium serum concentrations, requiring close monitoring.