Product image of Nalgesin (Naproxen Sodium) supplied by GNH India

Nalgesin

Active Ingredient:
Naproxen Sodium
Origin:
EU

Nalgesin (Naproxen Sodium)

Naproxen sodium, the active ingredient in Nalgesin, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It provides analgesic, anti‑inflammatory and antipyretic effects for the treatment of pain, fever and inflammatory conditions in adults.

GNH India supplies Nalgesin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution. All batches are manufactured under GMP conditions and are approved for export to EU markets.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Nalgesin (naproxen sodium) exerts its therapeutic effect by reducing inflammation and pain in several musculoskeletal and systemic conditions.

  • Pain: provides relief of mild to moderate acute or chronic pain.
  • Inflammation: diminishes swelling associated with inflammatory disorders.
  • Fever: lowers elevated body temperature.
  • Rheumatoid arthritis: alleviates joint pain and stiffness.
  • Osteoarthritis: improves mobility and reduces joint discomfort.
  • Dysmenorrhea: eases menstrual‑related cramping and pain.

How It Works

  • Naproxen sodium reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, leading to decreased synthesis of prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels, the drug diminishes peripheral sensitization of nociceptors and lowers the hypothalamic set‑point for temperature regulation.

Side Effects

Naproxen sodium may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal upset: nausea, indigestion or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Mild skin rash or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Severe cardiovascular events such as myocardial infarction or stroke.
  • Renal impairment or acute kidney injury.
  • Hepatic dysfunction or jaundice.
  • Life‑threatening skin reactions (e.g., Stevens‑Johnson syndrome).

Precautions & Warnings

When prescribing or dispensing Nalgesin, consider the following safety measures.

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
  • Monitor renal function: adjust use in patients with renal impairment.
  • Evaluate cardiovascular status: use cautiously in those with heart disease.
  • Use the lowest effective dose: limit duration to the shortest period necessary.
  • Avoid concomitant anticoagulants: increased risk of bleeding.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Nalgesin can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Antiplatelet agents (e.g., clopidogrel): additive anticoagulant effect.
  • Selective serotonin reuptake inhibitors (SSRIs): increased gastrointestinal bleeding.

Moderate Interactions (Monitor Closely):\n- Diuretics: may reduce renal clearance of naproxen.

  • Methotrexate: potential for increased toxicity.
  • Corticosteroids: synergistic risk of ulceration.

Frequently Asked Questions

Nalgesin contains naproxen sodium, an NSAID that is used to relieve mild to moderate pain, reduce fever, and treat inflammatory conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal injuries, and dysmenorrhea. It is prescribed for adults who need anti‑inflammatory and analgesic therapy.

Naproxen sodium works by reversibly blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for the production of prostaglandins. By lowering prostaglandin levels, it reduces inflammation, diminishes pain signals, and helps lower elevated body temperature.

The appropriate dose of Nalgesin is determined by a qualified healthcare professional based on the individual’s condition, age, weight, and response to therapy. Patients should follow the prescriber’s instructions and not alter the dose without medical advice.

Safety of naproxen sodium during pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a healthcare provider.

To order Nalgesin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both Nalgesin (naproxen sodium) and ibuprofen belong to the NSAID class and share similar mechanisms of action. Naproxen generally has a longer half‑life, allowing less frequent dosing, while ibuprofen may have a quicker onset. Choice between them depends on clinical response, dosing convenience, and individual safety considerations.

Nalgesin should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight to maintain its stability throughout its shelf life.

Nalgesin is administered orally, typically as a tablet swallowed with a full glass of water. It may be taken with food or milk to lessen gastrointestinal irritation, but patients should follow the specific instructions provided by their prescriber.

The most serious risks include gastrointestinal bleeding or ulcer perforation, cardiovascular events such as heart attack or stroke, severe renal impairment, and rare but life‑threatening skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of these conditions.

Nalgesin should be avoided in individuals with known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulcer disease, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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