Product image of Nalgesin (Naproxen Sodium) supplied by GNH India

Nalgesin

Active Ingredient:
Naproxen Sodium
Origin:
EU

Nalgesin (Naproxen Sodium)

Naproxen sodium, the active ingredient in Nalgesin, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It relieves mild to moderate pain, reduces inflammation, and lowers fever in adults.

GNH India supplies Nalgesin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets and providing reliable logistics for global distribution.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Nalgesin, an NSAID, is employed to manage conditions that involve pain, inflammation, or fever.

  • Pain: provides relief of mild to moderate pain such as headache, dental pain, or musculoskeletal discomfort.
  • Osteoarthritis: reduces joint inflammation and improves mobility in degenerative joint disease.
  • Rheumatoid arthritis: alleviates inflammatory joint symptoms and swelling.
  • Dysmenorrhea: eases menstrual cramps and associated pelvic pain.
  • Fever: lowers elevated body temperature in febrile states.

How It Works

  • Naproxen sodium exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition decreases the conversion of arachidonic acid to prostaglandins, leading to reduced synthesis of mediators that cause inflammation, pain, and fever.

Side Effects

Adverse reactions may range from mild to serious and should be monitored during therapy.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Rash: mild skin irritation or erythema.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Severe skin reactions including Stevens‑Johnson syndrome.
  • Renal impairment or hepatic injury.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
  • Monitor renal function: especially in patients with pre‑existing kidney disease.
  • Use the lowest effective dose: to minimise systemic exposure.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Caution with cardiovascular disease: weigh benefits against thrombotic risk.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Naproxen sodium can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible reduction in antihypertensive effect.
  • Diuretics: risk of reduced renal perfusion.
  • Methotrexate: potential for increased toxicity.

Frequently Asked Questions

Nalgesin contains naproxen sodium, an NSAID that is commonly prescribed to relieve mild to moderate pain, reduce inflammation in osteoarthritis and rheumatoid arthritis, alleviate menstrual cramps (dysmenorrhea), and lower fever associated with various illnesses.

Naproxen sodium works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes. This blockade reduces the formation of prostaglandins, which are chemical mediators responsible for pain, inflammation, and fever, thereby providing symptomatic relief.

The appropriate dose of Nalgesin is determined by a qualified prescriber based on the individual’s medical condition, age, weight, and response to therapy. Patients should follow the dosing instructions provided by their healthcare professional.

Safety of naproxen sodium in pregnancy or while breastfeeding has not been definitively established. Healthcare providers usually advise caution, especially in the third trimester, and may recommend alternative therapies when appropriate.

To place an order, submit an enquiry on the Nalgesin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both nalgesin (naproxen sodium) and ibuprofen belong to the NSAID class and share similar mechanisms of COX inhibition. Naproxen generally has a longer half‑life, allowing less frequent dosing, while ibuprofen may have a slightly faster onset. Choice depends on clinical judgment, patient tolerance and specific therapeutic goals.

Nalgesin should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.

Nalgesin is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. Patients should swallow the tablet whole and not crush or chew it.

The most serious risks include gastrointestinal bleeding or ulcer perforation, cardiovascular events such as heart attack or stroke, severe skin reactions like Stevens‑Johnson syndrome, and significant renal or hepatic impairment. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, unexplained bruising, or skin rash.

Nalgesin should be avoided by individuals with a known hypersensitivity to naproxen or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, or uncontrolled hypertension. It is also contraindicated in patients who have experienced recent cardiovascular events or severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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