Product image of Nalgesin Pro (Naproxen Sodium) supplied by GNH India

Nalgesin Pro

Active Ingredient:
Naproxen Sodium
Origin:
EU

Nalgesin Pro (Naproxen Sodium)

Naproxen sodium, the active ingredient in Nalgesin Pro, is a nonsteroidal anti-inflammatory drug presented as an oral formulation for systemic use. It is used to relieve mild to moderate pain, reduce inflammation in conditions such as osteoarthritis and rheumatoid arthritis, and lower fever in adult patients.

GNH India supplies Nalgesin Pro as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable sourcing for global healthcare providers through.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Naproxen sodium is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Mild to moderate pain: Provides analgesic relief for conditions such as headache, dental pain, or musculoskeletal discomfort.
  • Osteoarthritis and rheumatoid arthritis: Decreases joint inflammation and improves mobility.
  • Dysmenorrhea: Relieves menstrual cramps and associated pelvic pain.
  • Fever: Lowers elevated body temperature in acute febrile states.

How It Works

  • Naproxen sodium exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation throughout the body.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: Dyspepsia, abdominal pain, or heartburn.
  • Nausea and vomiting: Transient episodes after oral intake.
  • Headache: Mild to moderate intensity.
  • Dizziness or vertigo: May affect balance.
  • Skin rash: Mild erythema or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: Can be life‑threatening.
  • Cardiovascular events: Increased risk of myocardial infarction or stroke.
  • Renal impairment: Acute kidney injury, especially in dehydrated patients.
  • Hepatic enzyme elevation: Potential liver function abnormalities.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylaxis: Rare but requires immediate medical attention.

Precautions & Warnings

Before initiating therapy, consider patient‑specific risk factors and monitor appropriately.

  • Assess gastrointestinal risk: Review history of ulcers, bleeding disorders, or chronic NSAID use.
  • Evaluate cardiovascular status: Use cautiously in patients with hypertension, heart disease, or stroke risk.
  • Monitor renal function: Check serum creatinine and electrolytes in those with kidney disease or dehydration.
  • Check hepatic health: Perform liver function tests if pre‑existing liver disease is present.
  • Use the lowest effective dose: Limit duration to the shortest period needed for symptom control.
  • Store at ambient temperature: Keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Naproxen sodium can alter the pharmacodynamics or pharmacokinetics of several co‑administered drugs.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): Increased risk of serious bleeding.
  • Other NSAIDs or aspirin: Heightened gastrointestinal toxicity.
  • Corticosteroids: Synergistic ulcerogenic effect.
  • Lithium: Reduced renal clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): May modestly raise bleeding risk.
  • Diuretics and antihypertensives: Potential reduction in antihypertensive efficacy.
  • Methotrexate: Decreased renal elimination, raising toxicity potential.

Frequently Asked Questions

Nalgesin Pro contains naproxen sodium, an NSAID indicated for the relief of mild to moderate pain, reduction of inflammation in osteoarthritis and rheumatoid arthritis, management of dysmenorrhea, and lowering of fever in adult patients. It is prescribed when a non‑opioid analgesic and anti‑inflammatory effect is required.

Naproxen sodium works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By reducing prostaglandin production, it diminishes the inflammatory response, pain signaling, and fever generation throughout the body.

The specific dosage of Nalgesin Pro is determined by the prescribing healthcare professional based on the individual’s condition, severity, age, and renal or hepatic function. Patients should follow the prescriber’s instructions and not alter the dose without medical guidance.

Safety of naproxen sodium in pregnancy or lactation has not been definitively established. It is generally avoided in the third trimester of pregnancy due to potential fetal risks, and caution is advised during breastfeeding because the drug can be excreted in milk. Consultation with a healthcare provider is essential before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Naproxen sodium, the active ingredient in Nalgesin Pro, has a longer half‑life than ibuprofen, allowing less frequent dosing for chronic conditions. Compared with selective COX‑2 inhibitors, it is non‑selective and may carry a higher gastrointestinal risk but has a lower cardiovascular risk profile. Choice depends on patient‑specific factors and therapeutic goals.

Nalgesin Pro should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original blister or bottle, protect them from moisture, heat, and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Nalgesin Pro is taken orally with a full glass of water. It may be taken with or without food, although taking it with food can reduce gastrointestinal discomfort. Patients should swallow the tablet whole and not crush or chew it unless specifically instructed by a healthcare professional.

The most serious risks include gastrointestinal ulceration or bleeding, cardiovascular events such as heart attack or stroke, acute kidney injury, severe skin reactions like Stevens‑Johnson syndrome, and anaphylactic reactions. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, black stools, chest pain, shortness of breath, or rash.

Nalgesin Pro is contraindicated in individuals with a known hypersensitivity to naproxen or other NSAIDs, those with active gastrointestinal bleeding or ulcer disease, severe heart failure, and patients who have had a recent coronary artery bypass graft. It should also be avoided in the third trimester of pregnancy and used with caution in patients with renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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