Product image of Nalgesin S (Naproxen Sodium) supplied by GNH India

Nalgesin S

Active Ingredient:
Naproxen Sodium
Origin:
EU

Nalgesin S (Naproxen Sodium)

Naproxen sodium, the active ingredient in Nalgesin S, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is used to relieve mild to moderate pain, reduce inflammation in conditions such as arthritis, and lower fever in adults.
GNH India supplies Nalgesin S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Nalgesin S belongs to the NSAID class and is indicated for several painful and inflammatory conditions.

  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, and musculoskeletal discomfort.
  • Osteoarthritis: reduces joint inflammation and improves mobility.
  • Rheumatoid arthritis: alleviates chronic inflammatory symptoms.
  • Dysmenorrhea: eases menstrual cramps and associated discomfort.
  • Fever: helps lower elevated body temperature.

How It Works

  • Naproxen sodium exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which decreases the synthesis of prostaglandins responsible for pain, inflammation, and fever. This reduction in prostaglandin levels leads to the observed analgesic, anti‑inflammatory, and antipyretic actions.

Side Effects

Adverse reactions may occur with any NSAID, including naproxen sodium.

Common Side Effects

  • Gastrointestinal discomfort: dyspepsia, nausea, or abdominal pain.
  • Headache or dizziness.
  • Mild skin rash or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Renal impairment or reduced kidney function.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome).
  • Hepatic enzyme elevation or liver injury.

Precautions & Warnings

Before initiating therapy, several safety considerations should be reviewed.

  • Assess renal function: avoid use in patients with severe renal impairment.
  • Monitor gastrointestinal health: increased risk of ulcer or bleeding, especially with a history of GI disease.
  • Evaluate cardiovascular risk: use cautiously in patients with established heart disease or thrombotic risk.
  • Avoid concurrent use with other NSAIDs or anticoagulants: heightened bleeding potential.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Naproxen sodium can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Lithium: naproxen may raise lithium serum concentrations.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible decline in renal function.
  • Corticosteroids: additive risk of gastrointestinal ulceration.

Frequently Asked Questions

Nalgesin S contains naproxen sodium, an NSAID indicated for relief of mild to moderate pain, reduction of inflammation in osteoarthritis and rheumatoid arthritis, treatment of dysmenorrhea, and lowering of fever. It is prescribed for adult patients when a non‑opioid analgesic and anti‑inflammatory option is appropriate.

Naproxen sodium works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes. This inhibition reduces the production of prostaglandins, which are mediators that cause pain, swelling, and fever. Lower prostaglandin levels result in the analgesic, anti‑inflammatory, and antipyretic effects observed with the drug.

The specific dose of Nalgesin S is determined by the prescribing healthcare professional based on the individual’s condition, age, weight, and response to therapy. Dosage regimens may vary, and patients should follow the prescriber’s instructions without altering the amount or frequency on their own.

Safety data for naproxen sodium in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider. Breastfeeding mothers should consult their clinician before use.

To request Nalgesin S, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will ask for trade or institutional credentials. The sales team then provides pricing, availability, shipping details, and any necessary import documentation.

Nalgesin S (naproxen sodium) and ibuprofen are both NSAIDs with similar mechanisms, but naproxen has a longer half‑life, allowing less frequent dosing. Both share comparable efficacy for pain and inflammation, yet individual tolerability, gastrointestinal risk, and cardiovascular profile may differ, so clinicians choose based on patient‑specific factors.

Nalgesin S should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and excessive heat. Keep the product out of reach of children and avoid exposure to direct sunlight or humidity, which could affect tablet integrity.

Nalgesin S is administered orally. The tablets should be swallowed whole with a full glass of water, preferably with food or milk to lessen gastrointestinal irritation. Patients should not crush, chew, or split the tablets unless specifically instructed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulcer perforation, renal impairment, cardiovascular events such as heart attack or stroke, severe skin reactions like Stevens‑Johnson syndrome, and liver injury. Patients should seek immediate medical attention if they notice black stools, sudden kidney problems, chest pain, or unexplained rash.

Nalgesin S should be avoided in individuals with known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulceration, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment. It is also contraindicated in patients who have experienced a recent myocardial infarction or stroke without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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