Product image of Nalgesin S (Naproxen Sodium) supplied by GNH India

Nalgesin S

Active Ingredient:
Naproxen Sodium
Origin:
EU

Nalgesin S (Naproxen Sodium)

Naproxen Sodium, the active ingredient in Nalgesin S, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for systemic use. It is used to relieve mild to moderate pain, reduce inflammation in conditions such as arthritis, and lower fever in adult patients.

GNH India supplies Nalgesin S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Nalgesin S, an NSAID, acts on inflammatory pathways to provide symptomatic relief in several common conditions.

  • Mild to moderate pain: reduces pain intensity and improves functional ability.
  • Osteoarthritis and rheumatoid arthritis: diminishes joint inflammation and stiffness.
  • Fever: lowers elevated body temperature associated with acute infections or inflammatory states.

How It Works

  • Naproxen Sodium exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, pain signaling, and fever generation at the site of tissue injury or systemic response.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Gastrointestinal upset: dyspepsia, nausea, or abdominal discomfort.
  • Headache or dizziness.
  • Mild skin rash or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Renal impairment or reduced kidney function.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Severe skin reactions including Stevens‑Johnson syndrome.
  • Hepatic dysfunction with elevated liver enzymes.

Precautions & Warnings

Before initiating therapy, consider patient‑specific risk factors and monitor appropriately.

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
  • Monitor renal function: especially in patients with pre‑existing kidney disease.
  • Use the lowest effective dose for the shortest duration needed.
  • Avoid in individuals with known hypersensitivity to naproxen or other NSAIDs.
  • Take with food or an antacid to lessen stomach irritation.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Naproxen Sodium can affect the safety or efficacy of several co‑administered medicines.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened ulcer risk.
  • Lithium: elevated lithium serum concentrations.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely):\n- Diuretics: possible reduction in renal perfusion.

  • Antihypertensives (e.g., ACE inhibitors, ARBs): may blunt blood pressure control.
  • Oral hypoglycemics: potential alteration of glucose levels.

Frequently Asked Questions

Nalgesin S contains naproxen sodium, an NSAID that is commonly prescribed to relieve mild to moderate pain, reduce inflammation in arthritic conditions such as osteoarthritis and rheumatoid arthritis, and lower fever associated with infections or inflammatory processes.

Naproxen sodium blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. By lowering prostaglandin levels, it diminishes inflammation, reduces pain signaling, and helps bring down elevated body temperature.

The appropriate dose of Nalgesin S is determined by a qualified prescriber based on the individual’s medical condition, age, weight, and response to therapy. Patients should follow the dosing instructions provided by their healthcare professional.

Safety of naproxen sodium in pregnancy or while nursing has not been fully established. It is generally advised to avoid NSAIDs, especially in the third trimester, unless the benefits outweigh the risks. Pregnant or breastfeeding individuals should discuss alternatives with their doctor.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both naproxen sodium and ibuprofen belong to the NSAID class and share similar mechanisms of COX inhibition. Naproxen generally has a longer half‑life, allowing less frequent dosing, while ibuprofen may have a quicker onset. Choice between them depends on clinical judgment, patient tolerance, and specific therapeutic goals.

Nalgesin S should be stored at room temperature, below 25 °C. Keep the tablets in their original packaging, protect them from moisture, heat and direct sunlight to maintain potency throughout the shelf life.

Nalgesin S is taken orally, usually with a full glass of water. For optimal gastrointestinal tolerance, it can be taken with food or an antacid, unless otherwise directed by the prescribing clinician.

Serious risks include gastrointestinal bleeding or ulceration, severe cardiovascular events such as heart attack or stroke, renal impairment, and rare but severe skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of bleeding, chest pain, sudden kidney problems, or skin rash.

Individuals with a known allergy to naproxen or any NSAID, those with active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment should avoid using Nalgesin S. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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