Product image of Nalgesin S (Naproxen Sodium) supplied by GNH India

Nalgesin S

Active Ingredient:
Naproxen Sodium
Origin:
EU

Nalgesin S (Naproxen Sodium)

Naproxen sodium, the active ingredient in Nalgesin S, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for systemic use. It is used to relieve mild to moderate pain, reduce inflammation, and lower fever in adults. The medication belongs to the NSAID class and works by inhibiting cyclooxygenase enzymes, thereby decreasing prostaglandin production.

GNH India supplies Nalgesin S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Nalgesin S (naproxen sodium) is an NSAID that addresses pain and inflammatory conditions.

  • Musculoskeletal pain: provides analgesia and reduces inflammation associated with strains, sprains, and back pain.
  • Dental pain: alleviates postoperative or procedural dental discomfort.
  • Osteoarthritis: decreases joint pain and swelling, improving mobility.
  • Rheumatoid arthritis: helps control inflammatory joint pain and stiffness.
  • Dysmenorrhea: relieves menstrual cramps and associated discomfort.
  • Fever: lowers elevated body temperature.

How It Works

  • Naproxen sodium reversibly inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, leading to reduced conversion of arachidonic acid to prostaglandins. The lowered prostaglandin levels diminish inflammation, pain signaling, and fever generation, providing symptomatic relief in a variety of acute and chronic conditions.

Side Effects

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or mild abdominal discomfort.
  • Headache: transient pain often resolving without intervention.
  • Dizziness: occasional light‑headedness, especially when standing quickly.
  • Rash: mild skin irritation or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration: may present as black stools or vomiting blood.
  • Cardiovascular events: increased risk of heart attack or stroke, particularly with long‑term use.
  • Renal impairment: reduced kidney function manifesting as swelling or decreased urine output.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
  • Monitor renal function: especially in patients with pre‑existing kidney disease.
  • Use the lowest effective dose: limit duration to the shortest period necessary.
  • Avoid in patients with known hypersensitivity to naproxen or other NSAIDs.
  • Avoid concomitant use with other NSAIDs, anticoagulants, or antiplatelet agents unless medically justified.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Nalgesin S may interact with several medicines. Review the following:

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Lithium: naproxen can raise lithium serum concentrations.
  • Methotrexate: reduced clearance may lead to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible decline in renal function.
  • Diuretics: may impair renal perfusion when combined.
  • SSRIs or SNRIs: heightened bleeding tendency.

Frequently Asked Questions

Nalgesin S contains naproxen sodium, an NSAID indicated for the relief of mild to moderate pain such as musculoskeletal, dental, and postoperative pain, for reducing inflammation in osteoarthritis and rheumatoid arthritis, for treating dysmenorrhea, and for lowering fever.

Naproxen sodium blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are required for the synthesis of prostaglandins. By lowering prostaglandin levels, it diminishes inflammation, pain signaling, and fever responses.

The appropriate dose of Nalgesin S is determined by the prescribing healthcare professional based on the individual’s condition, age, renal and hepatic function, and other medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for naproxen sodium during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision. Breastfeeding mothers should consult their physician before use.

To order Nalgesin S, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both naproxen sodium (Nalgesin S) and ibuprofen belong to the NSAID class and share similar mechanisms. Naproxen generally has a longer half‑life, allowing twice‑daily dosing, whereas ibuprofen often requires three‑four times daily. Individual response, safety profile, and physician preference guide the choice.

Store Nalgesin S at room temperature, below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Nalgesin S is taken orally with a full glass of water. It may be taken with or without food, although taking it with food can reduce gastrointestinal discomfort. Swallow the tablet whole; do not crush or chew unless instructed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, cardiovascular events such as heart attack or stroke, and renal impairment that may manifest as reduced urine output or swelling. Patients should seek immediate medical attention if they notice black stools, chest pain, sudden shortness of breath, or severe swelling.

Nalgesin S should be avoided in individuals with known hypersensitivity to naproxen or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment. It is also contraindicated in patients taking certain anticoagulants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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