Product image of Nalgesin S (Naproxen Sodium) supplied by GNH India

Nalgesin S

Active Ingredient:
Naproxen Sodium
Origin:
EU

Nalgesin S (Naproxen Sodium)

Naproxen sodium, the active ingredient in Nalgesin S, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It provides analgesic, anti‑inflammatory and antipyretic effects for the relief of mild to moderate pain, inflammatory joint conditions such as osteoarthritis and rheumatoid arthritis, and fever in adult patients.

GNH India supplies Nalgesin S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality and regulatory standards.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Nalgesin S (naproxen sodium) is used to manage pain and inflammation across several musculoskeletal and systemic conditions.

  • Mild to moderate pain: Provides analgesic relief for acute or chronic pain episodes.
  • Osteoarthritis: Reduces joint pain and improves functional mobility.
  • Rheumatoid arthritis: Helps control inflammatory joint swelling and stiffness.
  • Musculoskeletal injuries: Alleviates pain and inflammation from strains, sprains and back pain.
  • Fever: Lowers elevated body temperature associated with infection or inflammation.

How It Works

  • Naproxen sodium exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which reduces the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels diminish inflammation, pain signaling, and fever generation at the site of tissue injury or infection.

Side Effects

Naproxen sodium may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal upset: dyspepsia, nausea or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Acute renal impairment or worsening of chronic kidney disease.
  • Severe cutaneous reactions, including Stevens‑Johnson syndrome.
  • Hepatic injury or elevated liver enzymes.
  • Anaphylaxis or other severe hypersensitivity reactions.

Precautions & Warnings

When prescribing or dispensing Nalgesin S, consider the following precautions to minimize risk.

  • Assess gastrointestinal risk: evaluate history of ulcers, bleeding or chronic NSAID use.
  • Monitor renal function: avoid in patients with severe renal impairment or dehydration.
  • Evaluate cardiovascular risk: use the lowest effective dose in patients with heart disease.
  • Use the lowest effective dose for the shortest duration needed.
  • Avoid in individuals with known hypersensitivity to naproxen or other NSAIDs.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Naproxen sodium can interact with other medicines; awareness of major and moderate interactions helps ensure safe use.

Major Interactions (Avoid)

  • Warfarin or other anticoagulants: increased risk of bleeding.
  • Concurrent use of other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or angiotensin receptor blockers: may reduce renal function.
  • Diuretics: potential for decreased renal perfusion.
  • Methotrexate: naproxen can raise methotrexate serum levels, increasing toxicity.

Frequently Asked Questions

Nalgesin S contains naproxen sodium, an NSAID indicated for the relief of mild to moderate pain, reduction of inflammation in conditions such as osteoarthritis and rheumatoid arthritis, and the control of fever. It is commonly prescribed for musculoskeletal pain, joint disorders and febrile states.

Naproxen sodium works by blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for the synthesis of prostaglandins. By lowering prostaglandin production, it reduces inflammation, diminishes pain signaling, and helps lower elevated body temperature.

The appropriate dose of Nalgesin S is determined by a qualified prescriber based on the individual’s medical condition, severity of symptoms, age, renal and hepatic function, and other concurrent medications. Patients should follow the prescribing information provided by their healthcare professional.

Safety of naproxen sodium in pregnancy and lactation has not been definitively established. It should be used only if clearly needed and after a risk‑benefit assessment by a healthcare professional. Breastfeeding mothers should consult their physician before using the product.

To place an order, submit an enquiry on the Nalgesin S product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both naproxen sodium (Nalgesin S) and ibuprofen belong to the NSAID class and share similar mechanisms of action. Naproxen generally has a longer half‑life, allowing less frequent dosing, while ibuprofen may have a quicker onset. Choice between them depends on patient‑specific factors, tolerability, and physician preference.

Store Nalgesin S at ambient temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture, direct sunlight and excessive heat to maintain product stability.

Nalgesin S is taken orally, usually with a full glass of water. It may be taken with food or milk to reduce gastrointestinal discomfort, but patients should follow the specific instructions given by their prescriber.

Serious risks include gastrointestinal bleeding or ulceration, cardiovascular events such as heart attack or stroke, acute kidney injury, severe skin reactions (e.g., Stevens‑Johnson syndrome), and anaphylactic reactions. Patients should seek immediate medical attention if they experience symptoms like black stools, chest pain, sudden swelling, or rash.

Nalgesin S should be avoided in individuals with known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, uncontrolled hypertension, and in patients who have had recent cardiovascular events unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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