Product image of Naloxon B. Braun (Naloxone Hydrochloride) supplied by GNH India

Naloxon B. Braun

Active Ingredient:
Naloxone Hydrochloride
Origin:
EU

Naloxon B. Braun (Naloxone Hydrochloride)

Naloxone, the active ingredient in Naloxon B. Braun, is an opioid antagonist presented as a sterile solution for intramuscular and intravenous use. It rapidly reverses opioid overdose and opioid‑induced respiratory depression in emergency situations.
GNH India supplies Naloxon B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Naloxone is an opioid antagonist used in the management of opioid overdose and related respiratory depression.

  • Opioid overdose: rapid reversal of life‑threatening respiratory depression.
  • Opioid‑induced respiratory depression: restores adequate breathing in patients receiving opioid therapy.
  • Post‑operative opioid toxicity: counteracts excessive opioid effects after surgery.

How It Works

  • Naloxone acts as a competitive antagonist at μ‑opioid receptors, displacing opioid agonists from the receptor site. By blocking these receptors, it reverses the central nervous system and respiratory depressant effects of opioids, restoring normal ventilation and consciousness without producing opioid effects itself.

Side Effects

Naloxone is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Injection site pain
  • Nausea
  • Vomiting
  • Sweating
  • Tremor
  • Anxiety

Serious or Rare Side Effects

  • Acute pulmonary edema
  • Cardiac arrhythmia
  • Seizures
  • Hypertension
  • Severe hypotension
  • Anaphylactic allergic reaction

Precautions & Warnings

Naloxone should be used with careful clinical assessment and monitoring.

  • Assess airway and breathing before administration: ensure the patient requires reversal.
  • Confirm opioid exposure: verify recent opioid use or overdose suspicion.
  • Monitor vital signs continuously: watch for recurrence of respiratory depression.
  • Avoid repeated dosing unless clinically indicated: excess naloxone may precipitate acute withdrawal.
  • Use with caution in patients with cardiovascular disease: may cause arrhythmias.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Naloxone may interact with other drugs that affect the central nervous system or opioid pathways.

Major Interactions (Avoid)

  • Concurrent high‑dose opioid therapy: may require higher naloxone doses and increase risk of severe withdrawal.
  • Mixed agonist‑antagonist opioids (e.g., buprenorphine): naloxone can precipitate abrupt withdrawal.

Moderate Interactions (Monitor Closely)

  • Sedatives or CNS depressants (benzodiazepines, barbiturates): combined effect may still depress respiration.
  • Cardiovascular agents (beta‑blockers, anti‑arrhythmics): monitor heart rate and blood pressure.
  • Antihistamines: may mask early signs of an allergic reaction.

Frequently Asked Questions

Naloxon B. Braun contains naloxone, an opioid antagonist used to reverse the effects of opioid overdose and to treat opioid‑induced respiratory depression in emergency and clinical settings.

Naloxone competitively blocks μ‑opioid receptors, displacing opioid molecules and rapidly reversing their depressant effects on the central nervous system and breathing without activating the receptors itself.

The appropriate dose is determined by the prescribing clinician based on the severity of opioid exposure, the route of administration, and the patient’s clinical response.

Safety data in pregnancy and lactation are limited; the product should be used only if the potential benefit justifies any potential risk to the fetus or infant, and under medical supervision.

Submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and import documentation.

Naloxon B. Braun is a sterile injectable formulation of naloxone, the most widely used opioid antagonist. Compared with alternatives such as nalmefene, naloxone has a faster onset of action and is the standard of care for acute overdose reversal.

Store the product at 2‑8 °C in a refrigerator, protect it from light, and avoid freezing or shaking the vial. Keep it in the original packaging until use.

Naloxon B. Braun is administered by intramuscular or intravenous injection. The route and dose are selected by the healthcare professional based on the clinical situation and patient response.

Serious risks include acute pulmonary edema, cardiac arrhythmias, severe hypertension or hypotension, seizures, and rare anaphylactic reactions. Immediate monitoring after administration is essential.

Naloxon B. Braun should be avoided in patients with known hypersensitivity to naloxone or any component of the formulation, and used with caution in individuals with significant cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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