Product image of Naloxon B. Braun (Naloxone Hydrochloride) supplied by GNH India

Naloxon B. Braun

Active Ingredient:
Naloxone Hydrochloride
Origin:
EU

Naloxon B. Braun (Naloxone Hydrochloride)

Naloxone, the active ingredient in Naloxon B. Braun, is an opioid antagonist presented as a sterile solution for injection for intramuscular and intravenous use. It rapidly reverses the effects of opioid overdose in adults and children.
GNH India supplies Naloxon B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Naloxone is an opioid antagonist used to treat acute opioid overdose and related emergencies.

  • Acute opioid overdose: rapidly restores breathing and consciousness in patients with life‑threatening opioid toxicity.
  • Opioid‑induced respiratory depression: reverses severe respiratory depression caused by opioid drugs.
  • Opioid toxicity in emergency settings: provides prompt antagonism of mu‑opioid receptors to counteract overdose effects.

How It Works

  • Naloxone competitively binds to mu‑opioid receptors with higher affinity than most opioid agonists, displacing them and blocking further receptor activation. This antagonism quickly reverses opioid‑mediated analgesia, respiratory depression, and sedation, restoring normal respiratory drive and consciousness without activating the receptors itself.

Side Effects

Naloxone may cause a range of adverse reactions after administration.

Common Side Effects

  • Injection site pain
  • Nausea
  • Sweating

Serious or Rare Side Effects

  • Acute pulmonary edema
  • Cardiac arrhythmias
  • Anaphylactic reaction

Precautions & Warnings

Naloxon B. Braun should be used with careful clinical monitoring.

  • Assess respiratory status before administration: confirm need for opioid reversal.
  • Monitor cardiovascular function after reversal: watch for hypertension or arrhythmias.
  • Use with caution in opioid‑dependent patients: abrupt reversal can precipitate withdrawal.
  • Adjust dosing in pediatric patients as directed by the prescriber.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Naloxon B. Braun can interact with several drug classes.

Major Interactions (Avoid)

  • Concurrent potent opioid agonists may reduce reversal efficacy.
  • Use with mixed agonist‑antagonist opioids (e.g., buprenorphine) can precipitate severe withdrawal.
  • Co‑administration with vasopressors may mask hypotension.

Moderate Interactions (Monitor Closely)

  • Sedatives or CNS depressants may still cause respiratory depression after naloxone.
  • MAO inhibitors may increase the risk of hypertension.
  • Antihypertensive agents may potentiate blood pressure fluctuations.

Frequently Asked Questions

Naloxon B. Braun is used to rapidly reverse the effects of an acute opioid overdose. It restores breathing and consciousness by blocking opioid receptors, making it a critical emergency medication for patients who have taken excessive opioid doses.

Naloxone works as a competitive antagonist at mu‑opioid receptors. By binding more strongly than most opioid agonists, it displaces them from the receptor sites, stopping further opioid activity and quickly reversing respiratory depression and sedation.

The exact dose of Naloxon B. Braun is determined by the prescribing clinician based on the patient’s age, weight, severity of overdose, and clinical response. Typical adult regimens start with an initial 0.4‑2 mg IV or IM dose, but the prescriber sets the final regimen.

Safety data for naloxone in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Use is generally reserved for life‑threatening situations, and the benefits of treating opioid toxicity usually outweigh potential risks.

To order Naloxon B. Braun, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Naloxon B. Braun contains naloxone, which has a rapid onset and short duration of action compared with longer‑acting antagonists such as naltrexone. This makes it ideal for emergency reversal of overdose, whereas other agents are more suited for maintenance therapy in opioid dependence.

Naloxon B. Braun must be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or contains particles.

Naloxon B. Braun is administered by intramuscular or intravenous injection. The healthcare professional selects the route based on the clinical situation, injects the prescribed dose, and monitors the patient for reversal of opioid effects and any adverse reactions.

Serious risks include acute pulmonary edema, cardiac arrhythmias, and severe allergic reactions such as anaphylaxis. Immediate medical attention is required if any of these rare but life‑threatening events occur after administration.

Naloxon B. Braun should not be used in patients with known hypersensitivity to naloxone or any component of the formulation. Caution is also advised in individuals with severe cardiovascular disease, as rapid reversal can precipitate abrupt changes in blood pressure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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