Product image of Naloxon B. Braun (Naloxone Hydrochloride) supplied by GNH India

Naloxon B. Braun

Active Ingredient:
Naloxone Hydrochloride
Origin:
EU

Naloxon B. Braun (Naloxone Hydrochloride)

Naloxone Hydrochloride, the active ingredient in Naloxon B. Braun, is an opioid antagonist presented as a sterile injectable solution for intramuscular and intravenous use. It reverses opioid‑induced respiratory depression and sedation in emergency situations.
GNH India supplies Naloxon B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Naloxon B. Braun is an opioid antagonist used in emergency medicine to counteract the effects of opioid toxicity.

  • Acute opioid overdose: rapidly restores normal breathing and consciousness.
  • Opioid‑induced respiratory depression: reverses life‑threatening hypoventilation.
  • Post‑operative opioid sedation: quickly awakens patients experiencing excessive sedation after surgery.

How It Works

  • Naloxone Hydrochloride acts as a competitive antagonist at mu, kappa and delta opioid receptors. By displacing opioid agonists from these sites, it blocks their depressant effects on the central nervous system, rapidly restoring respiratory drive and consciousness without activating the receptors itself.

Side Effects

Naloxon B. Braun may cause a range of adverse reactions following administration.

Common Side Effects

  • Nausea
  • Vomiting
  • Sweating
  • Headache
  • Agitation
  • Elevated blood pressure

Serious or Rare Side Effects

  • Severe hypertension
  • Cardiac arrhythmia
  • Pulmonary edema
  • Seizures
  • Anaphylactic reaction

Precautions & Warnings

Naloxon B. Braun should be used with careful clinical assessment and monitoring.

  • Assess airway and breathing: confirm need for opioid reversal before injection.
  • Verify opioid overdose: ensure opioid involvement to avoid unnecessary antagonism.
  • Monitor vital signs: observe blood pressure, heart rate and oxygen saturation after dosing.
  • Adjust use in cardiovascular disease: patients with heart conditions may experience abrupt blood pressure changes.
  • Store at controlled room temperature: keep in original packaging, protect from light and moisture.

Avoid Interactions

Naloxon B. Braun can interact with other medications that affect the central nervous system or cardiovascular function.

Major Interactions (Avoid)

  • Concurrent potent opioids may diminish reversal effectiveness.
  • Use with monoamine oxidase inhibitors can precipitate hypertensive crisis.
  • Co‑administration with other opioid antagonists may cause additive effects.

Moderate Interactions (Monitor Closely)

  • Sedatives or benzodiazepines may increase risk of CNS depression after reversal.
  • Adrenergic agents can alter blood pressure responses.
  • Drugs that lower seizure threshold may increase seizure risk when naloxone is given.

Frequently Asked Questions

Naloxon B. Braun is used to rapidly reverse the effects of opioid overdose, including life‑threatening respiratory depression and excessive sedation. It is administered in emergency settings by qualified healthcare professionals to restore normal breathing and consciousness.

Naloxone works by competitively binding to mu, kappa and delta opioid receptors, displacing opioid molecules that are causing depression of the central nervous system. This blockade stops the opioids from exerting their effects, allowing normal respiratory and neurological function to return quickly.

The specific dose of Naloxon B. Braun is determined by the prescribing clinician based on the patient’s condition, the opioid involved, and the route of administration. Healthcare providers follow local guidelines and clinical judgment to select the appropriate amount.

Safety data for naloxone in pregnancy and lactation are limited. It is generally considered when the benefits of treating a life‑threatening opioid overdose outweigh potential risks. Clinicians should evaluate each case individually and discuss any concerns with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Naloxon B. Braun contains naloxone, the most widely used opioid antagonist due to its rapid onset and short duration of action, making it ideal for emergency reversal. Alternatives such as nalmefene have longer half‑lives but are less commonly used in acute settings. Choice depends on clinical scenario and local protocols.

Naloxon B. Braun should be stored at controlled room temperature, below 25 °C, in its original packaging. Protect the product from direct light, moisture and extreme temperatures. Do not freeze the solution; inspect for particulate matter before use.

The product is supplied as a sterile injectable solution for intramuscular or intravenous injection. Administration is performed by trained medical personnel, typically using a pre‑filled syringe or vial, with dosage adjusted to the patient’s clinical needs.

Serious risks include severe hypertension, cardiac arrhythmias, pulmonary edema, seizures, and rare anaphylactic reactions. Immediate monitoring of cardiovascular status and respiratory function after administration is essential to detect and manage these events promptly.

Naloxon B. Braun is contraindicated in patients with known hypersensitivity to naloxone or any component of the formulation. Caution is advised in individuals with pre‑existing cardiovascular disease, as abrupt opioid reversal can cause rapid blood pressure changes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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