Product image of Naloxon Inresa (Naloxone Hydrochloride Dihydrate) supplied by GNH India

Naloxon Inresa

Active Ingredient:
Naloxone Hydrochloride Dihydrate
Origin:
EU

Naloxon Inresa (Naloxone Hydrochloride Dihydrate)

Naloxone, the active ingredient in Naloxon Inresa, is an opioid antagonist presented as a sterile injectable solution for intramuscular and intravenous use. It rapidly reverses the effects of opioid overdose and opioid‑induced respiratory depression in emergency settings.
GNH India supplies Naloxon Inresa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Inresa Arzneimittel Gmbh

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Indications & Clinical Uses

Naloxone is an opioid antagonist used in emergency medicine to counteract opioid toxicity.

  • Opioid overdose: restores normal breathing and consciousness in patients with life‑threatening opioid intoxication.
  • Opioid‑induced respiratory depression: rapidly reverses slowed or stopped breathing caused by opioid administration.
  • Acute opioid toxicity: mitigates severe central nervous system depression and circulatory collapse due to opioid exposure.

How It Works

  • Naloxone acts as a competitive antagonist at μ‑opioid receptors, displacing opioid agonists without activating the receptor. By binding to these receptors, it blocks the pharmacologic effects of opioids, rapidly reversing analgesia, sedation, and respiratory depression while leaving endogenous opioid activity minimally affected.

Side Effects

Naloxone may cause a range of adverse reactions, most of which are related to its rapid reversal of opioid effects.

Common Side Effects

  • Nausea
  • Vomiting
  • Sweating
  • Headache
  • Dizziness
  • Injection site pain

Serious or Rare Side Effects

  • Hypertension
  • Cardiac arrest
  • Seizures
  • Anaphylaxis
  • Pulmonary edema
  • Arrhythmias

Precautions & Warnings

Naloxone should be administered with careful clinical assessment and monitoring.

  • Assess respiratory status: confirm depressed breathing before administration.
  • Verify opioid involvement: ensure opioid exposure is the likely cause.
  • Hypersensitivity: avoid in patients with known allergy to naloxone or formulation components.
  • Cardiovascular disease: use cautiously in patients with unstable heart conditions.
  • Acute withdrawal: monitor for signs of sudden opioid withdrawal, especially in dependent individuals.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Naloxone may interact with other drugs that affect the central nervous system or opioid pathways.

Major Interactions (Avoid)

  • Potent opioid agonists: concurrent use may reduce naloxone’s ability to reverse overdose.
  • Mixed agonist‑antagonist opioids (e.g., buprenorphine): can precipitate severe withdrawal.

Moderate Interactions (Monitor Closely)

  • Sedatives (benzodiazepines, barbiturates): respiratory depression may persist despite naloxone.
  • Monoamine oxidase inhibitors: increased risk of hypertensive events.
  • Adrenergic agents (e.g., epinephrine): may exacerbate hypertension after naloxone administration.

Frequently Asked Questions

Naloxon Inresa contains naloxone, an opioid antagonist used in emergency situations to reverse the effects of opioid overdose and opioid‑induced respiratory depression. It restores normal breathing and consciousness when administered promptly.

Naloxone binds competitively to μ‑opioid receptors without activating them, displacing opioid molecules that are causing sedation or respiratory depression. This blockade quickly restores normal neuronal activity and breathing.

The appropriate dose of Naloxon Inresa is determined by the prescribing clinician based on the patient’s condition, route of administration, and severity of opioid toxicity. Dosage may vary between intramuscular and intravenous routes.

Safety data for naloxone in pregnancy and lactation are limited, and the pregnancy category is unknown. Clinicians should weigh potential benefits against risks and consider alternative treatments when possible.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Naloxon Inresa provides the same rapid opioid‑reversal activity as other naloxone products. Compared with longer‑acting antagonists such as naltrexone, naloxone has a shorter half‑life, making it ideal for acute emergency use where quick onset and short duration are desired.

Naloxon Inresa should be stored at 2‑8 °C in a refrigerator, protected from light and moisture. Do not freeze or shake the vial. If temporary storage at controlled room temperature is unavoidable, limit exposure to less than 30 °C for no more than 24 hours.

Naloxon Inresa is supplied as a sterile injectable solution for intramuscular or intravenous injection. The route and speed of administration are determined by the healthcare professional based on the clinical scenario and patient response.

Serious risks include rapid onset of acute opioid withdrawal, hypertension, cardiac arrhythmias, seizures, and rare anaphylactic reactions. Immediate medical monitoring is essential after administration to manage these potential complications.

Naloxon Inresa should be avoided in individuals with known hypersensitivity to naloxone or any component of the formulation. Caution is advised for patients with severe cardiovascular disease, uncontrolled hypertension, or those receiving mixed agonist‑antagonist opioids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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