Product image of Naloxona B. Braun (Naloxone Hydrochloride) supplied by GNH India

Naloxona B. Braun

Active Ingredient:
Naloxone Hydrochloride
Origin:
EU

Naloxona B. Braun (Naloxone Hydrochloride)

Naloxone Hydrochloride, the active ingredient in Naloxona B. Braun, is an opioid antagonist presented as an injectable solution for intramuscular and intravenous use. It rapidly reverses the effects of opioid overdose in emergency situations.
GNH India supplies Naloxona B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

1
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Indications & Clinical Uses

Naloxona B. Braun is an opioid antagonist used in acute care to counteract opioid toxicity.

  • Opioid overdose: rapid reversal of life‑threatening respiratory depression.
  • Opioid‑induced respiratory depression: restores normal breathing in emergency settings.
  • Opioid toxicity in trauma or surgery: reestablishes consciousness and airway protection.

How It Works

  • Naloxone Hydrochloride acts as a competitive antagonist at µ‑opioid receptors, displacing opioid agonists and blocking their activation. By binding without activating the receptor, it quickly reverses opioid‑mediated analgesia, sedation, and respiratory depression, allowing normal neuronal signaling to resume.

Side Effects

Naloxona B. Braun may cause a range of adverse reactions following administration.

Common Side Effects

  • Nausea
  • Vomiting
  • Sweating
  • Headache
  • Agitation or anxiety
  • Increased blood pressure
  • Tachycardia

Serious or Rare Side Effects

  • Severe hypertension
  • Pulmonary edema
  • Seizures
  • Allergic reactions (rash, urticaria)
  • Anaphylaxis
  • Cardiac arrhythmias

Precautions & Warnings

Naloxona B. Braun requires careful clinical assessment before use.

  • Assess airway and breathing: ensure ventilation support is available before administration.
  • Check for opioid dependence: may precipitate acute withdrawal symptoms.
  • Avoid in patients with known hypersensitivity to naloxone or formulation excipients.
  • Use with caution in cardiovascular disease: may cause abrupt hypertension.
  • Monitor vital signs after dosing: watch for recurrent respiratory depression.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Naloxona B. Braun can interact with other substances that affect the central nervous system or cardiovascular function.

Major Interactions (Avoid)

  • Opioid agonists administered concurrently: may reduce reversal effectiveness.
  • Monoamine oxidase inhibitors: risk of severe hypertension when combined with naloxone.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: may require additional respiratory support.
  • Alcohol: can potentiate central nervous system depression after naloxone wears off.
  • Beta‑blockers: may mask tachycardia that signals withdrawal.

Frequently Asked Questions

Naloxona B. Braun contains naloxone hydrochloride, an opioid antagonist used to rapidly reverse life‑threatening respiratory depression caused by opioid overdose. It is administered in emergency settings to restore normal breathing and consciousness.

Naloxone binds competitively to µ‑opioid receptors without activating them, displacing opioid molecules and blocking their effects. This rapid receptor blockade stops opioid‑induced sedation and respiratory depression, allowing normal neuronal activity to resume.

The specific dose of Naloxona B. Braun is determined by the prescriber based on the patient’s clinical condition, the type of opioid involved, and the route of administration. Healthcare professionals follow established guidelines to select the appropriate amount.

Safety data for naloxone in pregnancy and lactation are limited. It is generally used only when the benefit to the mother outweighs potential risks to the fetus or infant. Clinicians should evaluate each case individually.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Naloxona B. Braun provides the same active ingredient, naloxone hydrochloride, as other branded or generic formulations. Differences may lie in packaging, storage requirements, and regulatory status, but the pharmacological effect—rapid opioid reversal—remains consistent across products.

Naloxona B. Braun should be stored at 2‑8 °C, refrigerated in its original container, protected from light, and never frozen or shaken. Maintaining the cold chain preserves drug potency and ensures safe administration.

The product is supplied for intramuscular or intravenous injection. Healthcare providers select the appropriate route based on the clinical scenario, inject the solution into a suitable muscle or vein, and monitor the patient for response and possible withdrawal symptoms.

Serious risks include severe hypertension, pulmonary edema, seizures, allergic reactions such as anaphylaxis, and cardiac arrhythmias. Immediate medical supervision is required to detect and manage these rare but potentially life‑threatening events.

Patients with known hypersensitivity to naloxone or any component of the formulation should not receive Naloxona B. Braun. Caution is also advised for individuals with severe cardiovascular disease, as abrupt reversal may cause hemodynamic instability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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