Product image of Naloxone Accord (Naloxone Hydrochloride) supplied by GNH India

Naloxone Accord

Active Ingredient:
Naloxone Hydrochloride
Origin:
EU

Naloxone Accord (Naloxone Hydrochloride)

Naloxone Hydrochloride, the active ingredient in Naloxone Accord, is an opioid antagonist presented as a sterile solution for intramuscular or intravenous use. It reverses the effects of opioid overdose in emergency situations.
GNH India supplies Naloxone Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Naloxone is an opioid antagonist used in the management of opioid overdose and related emergencies.

  • Opioid overdose: rapidly reverses respiratory depression and sedation caused by opioid toxicity.
  • Opioid‑induced respiratory depression during procedural sedation: restores adequate breathing.
  • Acute opioid toxicity in emergency settings: restores consciousness and normal vital signs.

How It Works

  • Naloxone acts as a competitive antagonist at μ‑opioid receptors, displacing opioid agonists and blocking their activation. By binding without activating the receptor, it rapidly reverses opioid‑mediated effects such as respiratory depression, sedation, and miosis, restoring normal neuronal signaling in the central nervous system.

Side Effects

Naloxone may cause a range of adverse reactions, most of which are related to abrupt opioid withdrawal or injection site irritation.

Common Side Effects

  • Nausea
  • Vomiting
  • Sweating
  • Headache
  • Agitation or anxiety
  • Increased blood pressure
  • Tachycardia

Serious or Rare Side Effects

  • Severe hypertension
  • Cardiac arrhythmia
  • Pulmonary edema
  • Seizures
  • Anaphylactic reaction
  • Significant local injection site necrosis

Precautions & Warnings

Naloxone should be used with careful clinical monitoring and awareness of specific safety considerations.

  • Assess opioid dependence: anticipate possible acute withdrawal symptoms.
  • Monitor vital signs: watch for changes in respiratory rate, blood pressure, and heart rate.
  • Avoid use in patients with known hypersensitivity to naloxone or its excipients.
  • Use cautiously in chronic opioid users: rapid reversal can precipitate severe withdrawal.
  • Do not mix with incompatible injectable solutions unless compatibility is confirmed.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Naloxone may interact with other drugs that influence opioid pathways or cardiovascular function.

Major Interactions (Avoid)

  • Concurrent opioid agonists: may diminish naloxone’s reversal effect if given simultaneously.
  • Vasopressors: can mask hypotensive responses after naloxone administration.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: may require higher naloxone doses to achieve reversal.
  • Alcohol: can potentiate central nervous system depression despite naloxone.
  • Anticholinergic agents: may increase risk of tachycardia when combined with naloxone.

Frequently Asked Questions

Naloxone Accord is used to rapidly reverse the effects of opioid overdose, including respiratory depression, sedation, and loss of consciousness, in emergency medical situations.

Naloxone competitively blocks μ‑opioid receptors, displacing opioid molecules and preventing them from activating the receptor, which quickly restores normal breathing and consciousness.

The dose of Naloxone Accord is determined by the prescribing clinician based on the severity of the overdose, patient weight, and route of administration; no fixed regimen is provided here.

Safety data for naloxone in pregnancy and lactation are limited; it should be used only if the potential benefit justifies any potential risk to the fetus or infant, and under medical supervision.

Submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Naloxone is the most widely used opioid antagonist for emergency reversal, offering rapid onset via intramuscular or intravenous routes. Alternatives such as nalmefene have longer duration but are less commonly stocked for acute overdose treatment.

Naloxone Accord should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen. Use aseptic technique when preparing for injection.

Naloxone Accord is supplied as a sterile solution for intramuscular or intravenous injection. The appropriate route and volume are selected by the healthcare professional based on the clinical scenario.

Serious risks include severe hypertension, cardiac arrhythmias, pulmonary edema, seizures, and rare anaphylactic reactions. Immediate medical monitoring is essential after administration.

Patients with known hypersensitivity to naloxone or any formulation component should avoid its use. Caution is advised in individuals with chronic opioid dependence due to risk of precipitated withdrawal.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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