Product image of Naloxone Accord-Uk (Naloxone Hydrochloride) supplied by GNH India

Naloxone Accord-Uk

Active Ingredient:
Naloxone Hydrochloride
Origin:
EU

Naloxone Accord-Uk (Naloxone Hydrochloride)

Naloxone, the active ingredient in Naloxone Accord-Uk, is an opioid antagonist presented as a sterile solution for intravenous use. It rapidly reverses the effects of opioid overdose in emergency situations. GNH India supplies Naloxone Accord-Uk as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Accord-Uk Limited

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Indications & Clinical Uses

Naloxone is an opioid antagonist used in the management of opioid overdose and related emergencies.

  • Opioid overdose: rapidly reverses respiratory depression and sedation caused by opioid toxicity.
  • Acute opioid toxicity: restores consciousness and normal breathing in emergency settings.
  • Post‑operative opioid excess: counteracts unintended opioid effects after surgery.

How It Works

  • Naloxone acts as a competitive antagonist at μ‑opioid receptors, displacing opioid agonists and blocking their activation. By binding to these receptors without activating them, it reverses opioid‑induced central nervous system depression, restoring respiratory drive and consciousness within minutes of administration.

Side Effects

Naloxone may cause a range of adverse reactions following intravenous administration.

Common Side Effects

  • Injection site pain: mild discomfort at the injection site.
  • Nausea: feeling of queasiness.
  • Vomiting: expulsion of stomach contents.
  • Sweating: increased perspiration.
  • Tremor: involuntary shaking.
  • Hypertension: temporary rise in blood pressure.

Serious or Rare Side Effects

  • Severe hypertension: marked increase in blood pressure requiring medical attention.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Pulmonary edema: fluid accumulation in the lungs.
  • Anaphylaxis: severe allergic reaction with potential airway compromise.

Precautions & Warnings

Naloxone should be used with awareness of specific safety considerations.

  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Breastfeeding: unknown; consider potential infant exposure.
  • Renal impairment: no dosage adjustment needed, but monitor patient.
  • Cardiovascular disease: monitor blood pressure and heart rate.
  • Concomitant opioid therapy: may precipitate acute withdrawal symptoms.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Naloxone can interact with other substances that affect the central nervous system or cardiovascular system.

Major Interactions (Avoid)

  • Opioid agonists: may cause abrupt withdrawal.
  • MAO inhibitors: risk of hypertensive crisis.
  • Tricyclic antidepressants: potential for severe hypertension.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: additive central nervous system depression.
  • Alcohol: additive central nervous system depression.
  • CYP3A4 inhibitors: may increase naloxone plasma levels, though effect is minimal.

Frequently Asked Questions

Naloxone Accord-Uk is used to rapidly reverse the effects of opioid overdose, including respiratory depression and loss of consciousness, in emergency medical situations.

Naloxone competitively binds to μ‑opioid receptors, displacing opioid molecules and blocking their activity, which quickly restores normal breathing and alertness.

The dose is determined by the prescribing clinician based on the patient’s condition, severity of overdose, and clinical guidelines. No fixed regimen is provided here.

Safety data are limited; it should be used only if the potential benefit justifies the potential risk to the fetus or infant. Consultation with a healthcare professional is essential.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Naloxone is the most widely used opioid antagonist for acute overdose reversal. Compared with alternatives such as nalmefene, naloxone has a shorter half‑life and is preferred for immediate emergency intervention.

Store the product at 2‑8 °C, keep it refrigerated, protect it from light, and avoid freezing or shaking the vial to maintain stability.

It is administered intravenously by a qualified healthcare professional, typically as a rapid push injection in a controlled clinical setting.

Serious risks include severe hypertension, cardiac arrhythmias, pulmonary edema, and rare anaphylactic reactions. Immediate medical monitoring is required after administration.

Patients with known hypersensitivity to naloxone or any component of the formulation should avoid its use. Caution is advised in individuals with severe cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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