Product image of Naloxone supplied by GNH India

Naloxone

Active Ingredient:
Naloxone
Origin:
EU

Naloxone

Naloxone, the active ingredient in Naloxone, is an opioid antagonist presented as a nasal formulation for intranasal use. It rapidly reverses the life‑threatening effects of opioid overdose in both adults and pediatric patients, restoring normal breathing and consciousness.

GNH India supplies Naloxone as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for cross‑border distribution. Products are manufactured in EU‑compliant facilities and shipped under controlled conditions to ensure potency.

Manufacturer / TM Owner

Dne Pharma As

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Indications & Clinical Uses

Naloxone is an opioid antagonist used in the management of opioid toxicity.

  • Opioid overdose: rapidly reverses respiratory depression and sedation caused by opioid agonists.
  • Opioid‑induced respiratory depression: restores adequate ventilation and oxygenation.
  • Acute opioid toxicity: quickly reestablishes consciousness and normal cardiovascular function.

How It Works

  • Naloxone acts as a competitive antagonist at μ‑opioid receptors, displacing opioid agonists and blocking their activation. By binding without activating the receptor, it reverses opioid‑mediated inhibition of respiratory centers and central nervous system activity, leading to restoration of normal breathing and alertness.

Side Effects

Naloxone may cause a range of adverse reactions after intranasal administration.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Headache.
  • Dizziness.
  • Nausea.
  • Sweating.
  • Tremor.

Serious or Rare Side Effects

  • Severe hypertension.
  • Cardiac arrhythmias.
  • Seizures.
  • Anaphylactic reaction.
  • Pulmonary edema.

Precautions & Warnings

Naloxone should be used with careful clinical assessment and monitoring.

  • Assess airway and breathing: confirm need for opioid reversal before administration.
  • Use only in suspected opioid overdose: avoid unnecessary exposure.
  • Hypersensitivity: do not administer to patients with known allergy to naloxone.
  • Monitor vital signs: observe respiratory and cardiovascular status after dosing.
  • Opioid dependence: be aware of possible acute withdrawal symptoms.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Naloxone may interact with other substances that affect the central nervous system.

Major Interactions (Avoid)

  • Opioid agonists (e.g., morphine, fentanyl): can precipitate acute opioid withdrawal when naloxone is given.
  • MAO inhibitors: may increase risk of hypertensive reactions.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: additive central nervous system depression.
  • Alcohol: enhances sedative effects and may impair recovery.
  • Tricyclic antidepressants: may raise seizure risk when combined with naloxone.

Frequently Asked Questions

Naloxone is used to reverse the life‑threatening effects of opioid overdose. It rapidly restores breathing and consciousness by blocking opioid activity at the central nervous system.

Naloxone works as a competitive antagonist at μ‑opioid receptors. By binding to these receptors without activating them, it displaces opioid molecules and stops their inhibitory effects on respiration and alertness.

The dose of Naloxone is determined by the prescribing clinician based on the patient’s condition, the severity of the overdose, and the route of administration. No fixed regimen is provided here.

Safety data for Naloxone in pregnancy and lactation are limited. Clinicians should weigh potential benefits against risks and consider alternative treatments when appropriate.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Naloxone is the most widely used opioid antagonist for emergency reversal. Compared with alternatives such as nalmefene, Naloxone has a shorter half‑life, which may require repeat dosing but provides rapid onset of action suitable for intranasal delivery.

Store Naloxone at room temperature, below 25 °C, in its original packaging. Keep it away from moisture and direct sunlight to maintain potency.

Naloxone is administered intranasally using a pre‑filled nasal spray device. The device is placed in one nostril and the dose is sprayed, allowing rapid absorption through the nasal mucosa.

Serious risks include severe hypertension, cardiac arrhythmias, seizures, anaphylaxis, and pulmonary edema. Immediate medical evaluation is required if any of these reactions occur.

Naloxone should not be used in individuals with a known hypersensitivity to the drug. It is also contraindicated when opioid overdose is not suspected, as it may precipitate withdrawal symptoms.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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