Product image of Naltreksonklorid Amomed (Naltrexone Hydrochloride) supplied by GNH India

Naltreksonklorid Amomed

Active Ingredient:
Naltrexone Hydrochloride
Origin:
EU

Naltreksonklorid Amomed (Naltrexone Hydrochloride)

Naltrexone Hydrochloride, the active ingredient in Naltreksonklorid Amomed, is an opioid antagonist presented as an oral dosage form for oral use. It is employed in the management of alcohol dependence and opioid dependence after detoxification.
GNH India supplies Naltreksonklorid Amomed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Amomed Pharma Gmbh

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Indications & Clinical Uses

Naltrexone Hydrochloride is used to treat disorders related to opioid and alcohol dependence.

  • Alcohol dependence: reduces cravings and supports maintenance of abstinence.
  • Opioid dependence (post‑detoxification): blocks opioid receptors to prevent relapse.
  • Prevention of relapse in opioid dependence: maintains opioid‑free state after initial withdrawal.

How It Works

  • Naltrexone Hydrochloride acts as a competitive antagonist at opioid mu, kappa and delta receptors. By binding to these receptors without activating them, it blocks the reinforcing and euphoric effects of opioid agonists and attenuates the neurochemical pathways that drive alcohol‑related reward, thereby reducing cravings and preventing relapse.

Side Effects

Naltrexone Hydrochloride may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: occasional tension‑type headache.
  • Dizziness: transient light‑headedness.
  • Fatigue: feeling of tiredness.
  • Insomnia: difficulty falling or staying asleep.
  • Gastrointestinal discomfort: abdominal cramping or diarrhea.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Depression or suicidal thoughts: mood changes requiring immediate medical attention.
  • Hypotension: marked drop in blood pressure.
  • Seizures: rare convulsive episodes.
  • Acute withdrawal syndrome: precipitated opioid withdrawal in dependent individuals.

Precautions & Warnings

Before initiating therapy with Naltrexone Hydrochloride, consider the following precautions.

  • Liver function assessment: evaluate baseline hepatic enzymes, especially in patients with liver disease.
  • Opioid withdrawal risk: ensure the patient is opioid‑free for at least 7‑10 days to avoid precipitated withdrawal.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk, as safety data are limited.
  • Concomitant CNS depressants: monitor for additive sedation or respiratory depression.
  • Renal impairment: adjust monitoring in patients with severe kidney disease.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Naltrexone Hydrochloride can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Opioid agonists (e.g., morphine, oxycodone): may precipitate acute withdrawal.
  • Hepatotoxic drugs (e.g., isoniazid, methotrexate): increase risk of liver injury.

Moderate Interactions (Monitor Closely)

  • Disulfiram: combined effect on alcohol aversion may intensify adverse reactions.
  • Benzodiazepines: additive central nervous system depression.
  • Antidepressants (SSRIs, SNRIs): monitor for mood changes.
  • Antihypertensives: possible additive hypotensive effect.
  • Immunosuppressants: monitor liver function and drug levels.

Frequently Asked Questions

Naltreksonklorid, containing naltrexone hydrochloride, is prescribed to help people with alcohol dependence and to support individuals who have completed opioid detoxification by blocking the effects of opioid drugs and reducing cravings.

Naltrexone hydrochloride works by competitively binding to opioid receptors (mu, kappa, and delta) without activating them. This blocks the rewarding effects of opioids and diminishes the neurochemical pathways that contribute to alcohol‑related cravings, helping to maintain abstinence.

The specific dose and dosing schedule of Naltreksonklorid are determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any concurrent medications. Patients should follow the prescriber’s instructions exactly.

Safety data for naltrexone hydrochloride in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and the decision should be made together with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Naltreksonklorid (naltrexone) is an oral opioid antagonist, whereas alternatives like naloxone are injectable and used for emergency overdose reversal. Naltrexone provides longer‑term blockade for maintenance therapy, while naloxone acts rapidly to reverse acute opioid effects.

Store Naltreksonklorid at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme heat to maintain its stability and potency.

Naltreksonklorid is taken orally, usually as a tablet. The patient swallows the tablet whole with water, following the dosage regimen prescribed by the healthcare provider.

Serious risks include liver toxicity, severe allergic reactions, and precipitated opioid withdrawal if taken by a person who is opioid‑dependent and has not completed an adequate washout period. Immediate medical attention is required if any of these occur.

Individuals who are currently dependent on opioids, have acute hepatitis or severe liver impairment, or have a known hypersensitivity to naltrexone or any excipients in the formulation should not use Naltreksonklorid. Consultation with a healthcare professional is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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