Product image of Naltrexon Accord (Naltrexone Hydrochloride) supplied by GNH India

Naltrexon Accord

Active Ingredient:
Naltrexone Hydrochloride
Origin:
EU

Naltrexon Accord (Naltrexone Hydrochloride)

Naltrexone Hydrochloride, the active ingredient in Naltrexon Accord, is a opioid antagonist presented as a tablet for oral use. It treats alcohol dependence and helps prevent relapse in opioid dependence after detoxification.

GNH India supplies Naltrexon Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Naltrexon Accord is an opioid antagonist indicated for disorders related to alcohol and opioid use.

  • Alcohol dependence: reduces cravings and supports sustained abstinence.
  • Opioid dependence (post‑detoxification): blocks opioid receptors to prevent relapse.
  • Prevention of relapse in opioid dependence: maintains opioid‑free status after withdrawal.

How It Works

  • Naltrexone Hydrochloride acts as a competitive antagonist at opioid µ, κ and δ receptors. By binding to these receptors without activating them, it blocks the effects of both endogenous opioids and exogenous opioid agonists, thereby diminishing reinforcement pathways that drive alcohol and opioid use.

Side Effects

Naltrexon Accord may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Headache: occasional tension‑type pain.
  • Dizziness: transient light‑headedness.
  • Fatigue: feeling of reduced energy.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe depression or suicidal thoughts.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

Before prescribing Naltrexon Accord, clinicians should consider several safety aspects.

  • Liver function assessment: evaluate hepatic enzymes prior to initiation.
  • Depression monitoring: watch for worsening mood or suicidal ideation.
  • Avoid in acute hepatitis: contraindicated in active liver disease.
  • Renal impairment caution: dose adjustment may be needed in severe renal failure.
  • Concomitant opioid use: discontinue opioid analgesics to avoid precipitated withdrawal.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Naltrexon Accord can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Opioid agonists (e.g., morphine, methadone, oxycodone): may precipitate acute withdrawal.
  • Opioid‑containing cough syrups: can trigger severe withdrawal symptoms.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: increased sedation risk when combined.
  • Hepatotoxic drugs (e.g., high‑dose acetaminophen): may exacerbate liver injury.
  • Certain antidepressants (e.g., SSRIs): monitor for additive central nervous system effects.

Frequently Asked Questions

Naltrexon Accord contains naltrexone hydrochloride and is prescribed to help individuals with alcohol dependence maintain abstinence and to prevent relapse in patients who have completed opioid detoxification.

Naltrexone acts as a competitive antagonist at µ, κ and δ opioid receptors, blocking the binding of both endogenous opioids and external opioid drugs, which reduces the rewarding effects that drive alcohol and opioid use.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s condition, treatment goals, and clinical response. Patients should follow the prescriber’s instructions exactly.

The safety of naltrexone during pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and discuss options with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Naltrexon Accord’s active ingredient, naltrexone, is the most widely used oral opioid antagonist. Compared with injectable formulations like naloxone, naltrexone provides longer‑lasting receptor blockade, making it suitable for maintenance therapy rather than emergency reversal.

Store the tablets at temperatures below 25 °C, in the original packaging, and protect them from moisture and direct sunlight to maintain potency.

Naltrexon Accord is taken orally, usually as a tablet swallowed whole with water. The exact timing and frequency are set by the prescribing clinician.

Serious risks include potential liver injury, severe depression or suicidal thoughts, and allergic reactions such as rash or anaphylaxis. Patients should seek immediate medical attention if these occur.

Individuals with acute hepatitis, severe liver impairment, or those currently receiving opioid analgesics should not use Naltrexon Accord. It is also contraindicated in patients with known hypersensitivity to naltrexone.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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