Product image of Naltrexon Molteni (Naltrexone Hydrochloride) supplied by GNH India

Naltrexon Molteni

Active Ingredient:
Naltrexone Hydrochloride
Origin:
EU

Naltrexon Molteni (Naltrexone Hydrochloride)

Naltrexone, the active ingredient in Naltrexon Molteni, is an opioid antagonist presented as an oral tablet for oral use. It is employed in the management of alcohol dependence and opioid dependence to reduce cravings and block the effects of opioids. It is indicated for adult patients who require support in maintaining abstinence from alcohol or opioids.

GNH India supplies Naltrexon Molteni as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU regulatory standards.

Manufacturer / TM Owner

L. Molteni And C. Dei F.Lli Alitti Società Di Esercizio S.P.A.

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Indications & Clinical Uses

  • Naltrexone is an opioid antagonist used in the treatment of substance‑use disorders.
  • Alcohol dependence: assists patients in maintaining abstinence by reducing cravings and blocking alcohol‑related reward pathways.
  • Opioid dependence: blocks opioid receptors to prevent euphoria and support detoxification.
  • Prevention of opioid relapse: diminishes the risk of relapse by attenuating the reinforcing effects of opioids.

How It Works

  • Naltrexone acts as a competitive antagonist at mu, kappa, and delta opioid receptors. By binding to these receptors without activating them, it blocks the pharmacological effects of both endogenous opioids and exogenous opioid substances, thereby reducing the rewarding and reinforcing properties that contribute to dependence and relapse.

Side Effects

Naltrexone may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Fatigue
  • Insomnia
  • Abdominal pain

Serious or Rare Side Effects

  • Hepatotoxicity (elevated liver enzymes, hepatitis)
  • Severe allergic reactions (rash, angioedema, anaphylaxis)
  • Depression or suicidal thoughts
  • Severe rash or skin reactions
  • Hepatic failure
  • Acute withdrawal precipitated in opioid‑dependent patients

Precautions & Warnings

  • When prescribing Naltrexon Molteni, clinicians should consider several safety precautions.
  • Liver function monitoring: assess baseline hepatic enzymes and repeat periodically.
  • Contraindication in acute hepatitis: avoid use in patients with active liver disease.
  • Avoid in opioid‑dependent patients without detoxification: risk of precipitated withdrawal.
  • Pregnancy and lactation: use only if potential benefit outweighs risk.
  • Drug‑induced hepatotoxicity: discontinue if transaminases rise >3× ULN.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Naltrexone can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Opioid analgesics: may precipitate withdrawal and reduce analgesia.
  • Disulfiram: increased risk of hepatotoxicity.
  • Methadone or buprenorphine: antagonism may cause loss of opioid effect.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase naltrexone levels.
  • CYP3A4 inducers (e.g., rifampin): may reduce efficacy.
  • Alcohol: concurrent use may exacerbate liver toxicity.

Frequently Asked Questions

Naltrexon Molteni contains naltrexone, which is prescribed to help people with alcohol dependence maintain abstinence and to support individuals with opioid dependence by blocking the effects of opioids, thereby reducing cravings and preventing relapse.

Naltrexone works by competitively binding to mu, kappa, and delta opioid receptors in the central nervous system. This binding blocks both endogenous and exogenous opioids from activating the receptors, which diminishes the rewarding sensations associated with alcohol and opioid use.

The appropriate dose of Naltrexon Molteni is determined by the prescribing healthcare professional based on the patient’s clinical condition, treatment goals, and response. Dosage regimens may vary, and the prescriber will provide specific instructions.

Safety data for naltrexone in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Naltrexone differs from alternatives such as acamprosate (for alcohol) or methadone/buprenorphine (for opioids) by acting as an opioid receptor antagonist rather than a substitute agonist. This mechanism reduces cravings without providing opioid effects, making it suitable for patients seeking abstinence rather than maintenance therapy.

Store Naltrexon Molteni at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Naltrexon Molteni is taken orally, typically as a tablet. The patient should swallow the tablet whole with water, following the dosing schedule prescribed by the healthcare professional.

Serious risks include hepatotoxicity, which may present as elevated liver enzymes or hepatitis, and severe allergic reactions such as anaphylaxis. Additionally, in opioid‑dependent individuals who have not completed detoxification, naltrexone can precipitate acute withdrawal, which requires immediate medical attention.

Naltrexon Molteni should be avoided in patients with active liver disease, acute hepatitis, or those currently dependent on opioids who have not undergone proper detoxification, as it can trigger severe withdrawal. It is also contraindicated in individuals with known hypersensitivity to naltrexone.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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