Product image of Naltrexona Accord (Naltrexone Hydrochloride) supplied by GNH India

Naltrexona Accord

Active Ingredient:
Naltrexone Hydrochloride
Origin:
EU

Naltrexona Accord (Naltrexone Hydrochloride)

Naltrexone, the active ingredient in Naltrexona Accord, is an opioid antagonist presented as an oral formulation for oral use. It is employed in the management of alcohol and opioid dependence in adult patients.

GNH India supplies Naltrexona Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for importers.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Naltrexona Accord is used to treat disorders related to opioid and alcohol dependence.

  • Alcohol dependence: reduces cravings and helps maintain abstinence in adults.
  • Opioid dependence: blocks opioid receptors to prevent relapse and diminish the rewarding effects of opioids.

How It Works

  • Naltrexona Accord contains naltrexone hydrochloride, which acts as a competitive antagonist at the mu, kappa and delta opioid receptors. By occupying these sites, it blocks the binding of endogenous opioids and exogenous opioid agonists, thereby inhibiting the downstream signaling that produces analgesia, euphoria and reinforcement. This antagonism underlies its utility in preventing relapse in opioid‑dependent individuals and reducing alcohol‑related reward pathways.

Side Effects

Naltrexona Accord may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Fatigue
  • Insomnia
  • Abdominal pain

Serious or Rare Side Effects

  • Hepatotoxicity
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Elevated liver enzymes
  • Depression or suicidal thoughts

Precautions & Warnings

Before initiating therapy with Naltrexona Accord, several safety considerations should be observed.

  • Liver function monitoring: assess baseline hepatic enzymes and repeat periodically.
  • Concomitant opioid use: avoid as it can precipitate acute withdrawal.
  • Pregnancy: use only if potential benefit justifies potential risk; data are limited.
  • Breastfeeding: not recommended; consider alternative therapies.
  • Renal impairment: adjust use cautiously and monitor renal function.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

Avoid Interactions

Naltrexona Accord can interact with other medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Opioid analgesics: can cause acute withdrawal.
  • Disulfiram: may increase hepatotoxic risk.
  • Hepatotoxic drugs (e.g., isoniazid): additive liver injury.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: combined CNS depression may occur.
  • Antidepressants (SSRIs, SNRIs): monitor for mood changes.
  • Alcohol: may enhance hepatotoxic potential.

Frequently Asked Questions

Naltrexona Accord is prescribed to help individuals with alcohol dependence and opioid dependence. It works by reducing cravings and blocking the rewarding effects of alcohol and opioids, supporting abstinence and relapse prevention.

Naltrexone is a competitive antagonist at mu, kappa and delta opioid receptors. By binding to these receptors without activating them, it blocks both endogenous opioids and external opioid drugs, preventing the usual physiological and psychological responses associated with their use.

The specific dose and dosing schedule of Naltrexona Accord are determined by the prescribing clinician based on the patient’s condition, treatment goals and clinical response. Patients should follow the prescriber’s instructions exactly.

Safety data for naltrexone in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs the possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To request Naltrexona Accord, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Naltrexona Accord contains naltrexone, a long‑acting oral antagonist, whereas drugs like naloxone are short‑acting and typically administered by injection for emergency overdose reversal. Naltrexone is preferred for maintenance therapy in dependence, while naloxone is used for acute reversal.

Store Naltrexona Accord at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Naltrexona Accord is taken orally, usually as a tablet or capsule, with or without food as directed by the prescriber. The medication should be swallowed whole and not chewed or crushed unless specifically instructed.

Serious risks include hepatotoxicity, severe allergic reactions such as anaphylaxis or angioedema, and the emergence of depression or suicidal thoughts. Patients should report any signs of liver dysfunction, rash, swelling, or mood changes to their healthcare provider promptly.

Naltrexona Accord is contraindicated in individuals with a known hypersensitivity to naltrexone or any of its excipients, those currently using opioid analgesics (due to risk of precipitated withdrawal), and patients with severe hepatic impairment without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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