Naltrexone Accord (Naltrexone Hydrochloride)

Naltrexone Hydrochloride blocks mu, kappa and delta opioid receptors throughout the central nervous system. By competitively antagonising these receptors, it prevents both endogenous opioids and external opioid agonists from activating the reward pathways that drive cravings for alcohol and opioids, thereby diminishing the desire to use these substances.

The specific dose of Naltrexone Accord is determined by the prescribing clinician based on the patient’s medical condition, treatment goals and tolerability. In clinical practice, a common starting point is 50 mg taken once daily, but the exact regimen should always follow the prescriber’s written instructions.

Safety data for Naltrexone during pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the Naltrexone Accord product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details and any necessary import documentation.

Naltrexone differs from alternatives such as acamprosate, which modulates glutamate transmission, and disulfiram, which causes an aversive reaction to alcohol. While acamprosate primarily supports abstinence, and disulfiram deters drinking through unpleasant effects, Naltrexone reduces the rewarding feeling of alcohol consumption, making it useful for patients who benefit from decreased craving rather than aversive therapy.

Naltrexone Accord should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Naltrexone Accord is taken orally as a tablet. The tablet should be swallowed whole with a glass of water, typically once daily, unless the prescribing clinician advises a different schedule. It is important to follow the exact instructions provided on the prescription label.

The most serious risks include potential liver injury, which may manifest as elevated liver enzymes or hepatitis, and severe allergic reactions such as anaphylaxis. Additionally, if taken by a person who has recently used opioids, Naltrexone can precipitate acute opioid withdrawal, which may be uncomfortable and require medical supervision.

Naltrexone Accord is contraindicated in individuals with acute or severe liver disease, those currently using opioid analgesics or opioid‑containing medications, and anyone with a known hypersensitivity to naltrexone or any of the tablet’s excipients. Patients should inform their healthcare provider of any existing conditions before starting therapy.