Product image of Naltrexone Accord (Naltrexone Hydrochloride) supplied by GNH India

Naltrexone Accord

Active Ingredient:
Naltrexone Hydrochloride
Origin:
EU

Naltrexone Accord (Naltrexone Hydrochloride)

Naltrexone Hydrochloride, the active ingredient in Naltrexone Accord, is an opioid antagonist presented as an oral dosage form for oral use. It is employed in the management of alcohol dependence and for relapse prevention in opioid dependence.
GNH India supplies Naltrexone Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Naltrexone Accord acts on opioid receptors to modify dependence‑related pathways.

  • Alcohol dependence: reduces cravings and supports abstinence in individuals with alcohol use disorder.
  • Opioid dependence (relapse prevention): blocks reinforcing effects of opioids, helping maintain sobriety after detoxification.
  • Opioid use disorder: diminishes the risk of relapse by antagonising mu‑opioid receptors.

How It Works

  • Naltrexone Hydrochloride competitively binds to mu (μ) opioid receptors without activating them, thereby blocking the euphoric and reinforcing effects of both alcohol and opioid substances. This antagonism reduces the neurochemical reward associated with substance use, supporting maintenance of abstinence in dependent individuals.

Side Effects

Naltrexone Accord may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Fatigue: feeling unusually tired.

Serious or Rare Side Effects

  • Hepatotoxicity: signs of liver injury such as jaundice.
  • Severe depression or suicidal thoughts: emergent mood changes.
  • Allergic reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Liver function assessment: evaluate hepatic enzymes due to potential hepatotoxicity.
  • Psychiatric monitoring: watch for worsening depression or suicidal ideation.
  • Concomitant opioid use: avoid abrupt discontinuation of opioids to prevent withdrawal.
  • Renal impairment: adjust use in patients with reduced kidney function.
  • Pregnancy and lactation: discuss risks with a healthcare professional.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Naltrexone may interact with several medications, requiring careful management.

Major Interactions (Avoid)

  • Opioid agonists: can precipitate acute withdrawal.
  • Alcohol: may increase hepatotoxic risk.
  • Hepatotoxic drugs (e.g., isoniazid): additive liver injury.

Moderate Interactions (Monitor Closely)

  • Antidepressants: monitor mood changes.
  • Benzodiazepines: enhanced sedation risk.
  • Rifampin: may reduce naltrexone plasma levels.

Frequently Asked Questions

Naltrexone Accord is prescribed for the management of alcohol dependence and for preventing relapse in individuals with opioid dependence. It works by reducing the rewarding effects of alcohol and opioids, helping patients maintain abstinence.

Naltrexone Hydrochloride acts as a competitive antagonist at the mu (μ) opioid receptors. By binding without activating these receptors, it blocks the euphoric and reinforcing signals produced by alcohol and opioid substances, thereby diminishing cravings and the risk of relapse.

The specific dose and dosing schedule of Naltrexone Accord are determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any relevant medical considerations.

Safety data for Naltrexone Accord in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against possible risks and discuss these considerations with the patient before initiating therapy.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Naltrexone Accord shares the same mechanism of action as other oral opioid antagonists such as naloxone, but it is formulated for chronic oral use rather than acute emergency reversal. Its long‑acting profile makes it suitable for maintenance therapy in alcohol and opioid dependence.

Store Naltrexone Accord at temperatures below 25 °C in its original packaging. Protect the product from moisture, excessive heat, and direct sunlight to maintain its stability and potency.

Naltrexone Accord is taken orally, usually with water. The exact timing (e.g., with or without food) and frequency are determined by the prescribing clinician based on individual treatment goals.

Serious risks include potential liver injury, severe depression, suicidal thoughts, and allergic reactions such as anaphylaxis. Patients should be monitored regularly for signs of hepatic dysfunction and mood changes, and any severe adverse events should prompt immediate medical attention.

Naltrexone Accord is contraindicated in individuals with acute hepatitis, severe liver impairment, or those currently using opioid analgesics or dependent on opioids without prior detoxification, as it may precipitate withdrawal. Consultation with a healthcare professional is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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