Product image of Naltrexone Poa Pharma (Naltrexone Hydrochloride) supplied by GNH India

Naltrexone Poa Pharma

Active Ingredient:
Naltrexone Hydrochloride
Origin:
EU

Naltrexone Poa Pharma (Naltrexone Hydrochloride)

Naltrexone Hydrochloride, the active ingredient in Naltrexone Poa Pharma, is an opioid antagonist presented as an oral tablet for oral use. It is employed in the management of alcohol dependence and opioid dependence in adult patients.
GNH India supplies Naltrexone Poa Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Poa Pharma Scandinavia Ab

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Indications & Clinical Uses

Naltrexone works within the opioid receptor pathway to reduce cravings and prevent relapse in substance‑use disorders.

  • Alcohol dependence: helps maintain abstinence by blocking rewarding effects of alcohol.
  • Opioid dependence: supports long‑term recovery by preventing opioid‑induced euphoria after detoxification.
  • Opioid use disorder relapse prevention: reduces risk of relapse when used as part of a comprehensive treatment program.

How It Works

  • Naltrexone Hydrochloride acts as a competitive antagonist at mu, kappa, and delta opioid receptors. By binding to these receptors without activating them, it blocks the effects of endogenous opioids and exogenous opioid agonists, thereby diminishing the reinforcing and euphoric properties of alcohol and opioid substances and reducing craving and relapse risk.

Side Effects

Naltrexone may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: transient gastrointestinal upset often occurring early in therapy.
  • Headache: mild to moderate intensity, usually resolves with continued use.
  • Dizziness: may be experienced during dose titration.
  • Fatigue: general tiredness reported by some patients.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury, requiring monitoring.
  • Severe depression or suicidal ideation: mood changes that need immediate medical attention.
  • Allergic reactions: rash, pruritus, or anaphylaxis in rare cases.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient history and monitor for specific risks.

  • Assess liver function: obtain baseline hepatic enzymes and monitor periodically.
  • Monitor for depression: watch for mood changes or suicidal thoughts.
  • Avoid in acute hepatitis: contraindicated in active severe liver disease.
  • Use caution with concomitant opioids: may precipitate acute withdrawal.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Naltrexone can interact with several medication classes, requiring careful management.

Major Interactions (Avoid)

  • Opioid agonists: can trigger sudden opioid withdrawal.
  • Alcohol: may increase sedation and hepatic strain.
  • Hepatotoxic drugs: combined use may elevate risk of liver injury.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: additive central nervous system depression.
  • Antidepressants: potential influence on mood and withdrawal symptoms.
  • CYP3A4 inhibitors: may raise plasma levels of naltrexone.

Frequently Asked Questions

Naltrexone Poa Pharma is prescribed for the treatment of alcohol dependence and opioid dependence. It helps reduce cravings and supports abstinence by blocking the rewarding effects of these substances when used as part of a comprehensive management plan.

Naltrexone Hydrochloride acts as a competitive antagonist at mu, kappa, and delta opioid receptors. By occupying these receptors without activating them, it prevents endogenous and exogenous opioids from producing their usual euphoric and reinforcing effects, thereby diminishing cravings and the risk of relapse.

The specific dose and dosing schedule are determined by the prescribing clinician based on the individual’s medical condition, treatment goals, and response. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

The safety of Naltrexone Hydrochloride in pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Naltrexone is an oral opioid antagonist with a long half‑life, offering convenient once‑daily dosing for many patients. Compared with injectable antagonists such as naloxone, it provides sustained receptor blockade but requires adherence to oral administration and may have a different side‑effect profile.

Store the product at room temperature, below 25 °C, in its original packaging. Protect it from excess moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Naltrexone Poa Pharma is taken orally, typically as a tablet swallowed with water. The exact timing relative to meals or other medications should follow the prescriber’s guidance to optimize absorption and minimize gastrointestinal discomfort.

Serious risks include hepatotoxicity, severe depression or suicidal thoughts, and rare allergic reactions such as anaphylaxis. Patients should be monitored regularly for liver function abnormalities and changes in mood, and any severe symptoms should prompt immediate medical evaluation.

Naltrexone is contraindicated in individuals with acute hepatitis, severe liver impairment, or those currently dependent on opioid analgesics without prior detoxification, as it can precipitate withdrawal. It should also be used with caution in patients with a history of severe depression.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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