Product image of Naltrexone Poa Pharma (Naltrexone Hydrochloride) supplied by GNH India

Naltrexone Poa Pharma

Active Ingredient:
Naltrexone Hydrochloride
Origin:
EU

Naltrexone Poa Pharma (Naltrexone Hydrochloride)

Naltrexone Hydrochloride, the active ingredient in Naltrexone Poa Pharma, is an opioid antagonist presented as an oral formulation for oral use. It is employed to support the management of opioid dependence and alcohol dependence in adult patients, helping to reduce cravings and prevent relapse.

GNH India supplies Naltrexone Poa Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Poa Pharma Scandinavia Ab

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Indications & Clinical Uses

Naltrexone Hydrochloride acts on the opioid system and is used in the following clinical situations:

  • Opioid dependence: assists in maintaining abstinence by blocking opioid effects.
  • Alcohol dependence: reduces cravings and supports abstinence.
  • Relapse prevention in opioid use disorder: helps prevent return to opioid use after detoxification.

How It Works

  • Naltrexone Hydrochloride works as a competitive antagonist at opioid receptors, primarily the mu‑opioid receptors. By binding to these receptors without activating them, it blocks the pharmacologic effects of both endogenous opioids and exogenous opioid agonists, thereby diminishing reinforcement, craving, and the euphoric response associated with opioid and alcohol use.

Side Effects

Adverse reactions may occur with Naltrexone Hydrochloride and are categorized by frequency.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Fatigue: reduced energy levels.
  • Insomnia: difficulty initiating sleep.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Depression or suicidal thoughts: mood changes requiring immediate medical attention.
  • Seizures: rare convulsive episodes.
  • Acute withdrawal: precipitated opioid withdrawal in recently used patients.

Precautions & Warnings

Before initiating therapy with Naltrexone Hydrochloride, consider the following safety measures:

  • Liver function assessment: evaluate baseline hepatic enzymes.
  • Depression monitoring: watch for mood changes or suicidal ideation.
  • Avoid use during acute opioid withdrawal: ensure opioid‑free status to prevent precipitated withdrawal.
  • Renal impairment caution: adjust use in patients with significant kidney disease.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Naltrexone Hydrochloride can interact with several medications; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Opioid analgesics (e.g., morphine, oxycodone): antagonizes analgesic effect and may precipitate withdrawal.
  • Opioid agonist therapy (methadone, buprenorphine): can cause sudden loss of opioid effect and precipitate withdrawal.
  • Disulfiram: combined use may increase risk of hepatotoxicity.

Moderate Interactions (Monitor Closely)

  • Alcohol: concurrent use may enhance hepatotoxic risk.
  • CNS depressants (benzodiazepines, barbiturates): may increase sedation and respiratory depression risk.
  • Rifampin: may reduce naltrexone plasma concentrations by inducing metabolism.

Frequently Asked Questions

Naltrexone Poa Pharma contains naltrexone hydrochloride, an opioid antagonist indicated for the management of opioid dependence and alcohol dependence in adult patients. It helps reduce cravings and supports abstinence in these conditions.

Naltrexone acts as a competitive antagonist at mu‑opioid receptors. By binding to these receptors without activating them, it blocks the effects of both endogenous opioids and external opioid drugs, thereby diminishing the rewarding and reinforcing properties that contribute to dependence.

The specific dose and dosing schedule of Naltrexone Poa Pharma are determined by the prescribing healthcare professional based on the individual’s clinical condition, treatment goals, and response to therapy. Patients should follow the prescriber’s instructions precisely.

The safety of naltrexone during pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing individuals.

To request Naltrexone Poa Pharma, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Naltrexone is a non‑selective opioid antagonist that blocks mu‑opioid receptors, similar to naloxone but with a longer oral half‑life, making it suitable for daily oral therapy. Unlike naloxone, which is used for acute overdose, naltrexone is primarily used for maintenance treatment of dependence.

Naltrexone Poa Pharma should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat, and direct sunlight to maintain stability.

The medication is administered orally, typically as a tablet taken with water. The exact timing and frequency are prescribed by the treating clinician, who will consider the patient’s overall treatment plan.

Serious risks include hepatotoxicity, severe allergic reactions such as anaphylaxis, and the potential for precipitating acute opioid withdrawal if taken before complete opioid clearance. Patients should be monitored for liver function abnormalities and signs of hypersensitivity.

Naltrexone is contraindicated in individuals currently using opioid agonists, those in acute opioid withdrawal, and patients with known hypersensitivity to naltrexone or any formulation components. Caution is also advised for patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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