Product image of Naltrexone Poa Pharma (Naltrexone Hydrochloride) supplied by GNH India

Naltrexone Poa Pharma

Active Ingredient:
Naltrexone Hydrochloride
Origin:
EU

Naltrexone Poa Pharma (Naltrexone Hydrochloride)

Naltrexone, the active ingredient in Naltrexone Poa Pharma, is an opioid antagonist presented as an oral formulation for oral use. It treats alcohol dependence and opioid dependence in adult patients, helping to reduce cravings and block the reinforcing effects of these substances.

GNH India supplies Naltrexone Poa Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Poa Pharma Scandinavia Ab

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Indications & Clinical Uses

Naltrexone is used in the management of disorders related to alcohol and opioid use, acting on the central nervous system to diminish reinforcing effects.

  • Alcohol dependence: reduces cravings and the risk of relapse in adults.
  • Opioid dependence: blocks opioid receptors to support abstinence and prevent relapse.

How It Works

  • Naltrexone acts as a competitive antagonist at opioid receptors, primarily the mu‑opioid receptor, preventing endogenous and exogenous opioids from activating the receptor. By blocking these receptors, it diminishes the rewarding and reinforcing effects of alcohol and opioid substances, thereby supporting treatment of dependence.

Side Effects

Naltrexone may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: occasional tension‑type headache.
  • Dizziness: transient light‑headedness.
  • Fatigue: feeling of reduced energy.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe depression or suicidal thoughts: mood changes requiring immediate attention.
  • Allergic reactions: rash, pruritus, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient history and monitor for specific risks.

  • Liver function assessment: check baseline enzymes and monitor periodically.
  • Depression monitoring: watch for mood changes, especially in patients with prior psychiatric illness.
  • Opioid use avoidance: do not co‑administer with opioid analgesics to prevent precipitated withdrawal.
  • Renal impairment caution: adjust monitoring in patients with reduced kidney function.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Naltrexone can interact with several medication classes, requiring careful management.

Major Interactions (Avoid)

  • Opioid agonists (e.g., morphine, oxycodone): may precipitate acute withdrawal.
  • Alcohol: concurrent use can increase hepatotoxic risk.
  • Disulfiram: combined hepatotoxic potential.

Moderate Interactions (Monitor Closely)

  • Antidepressants (e.g., SSRIs): monitor for additive central nervous system effects.
  • Antihypertensives: observe for possible blood pressure changes.

Frequently Asked Questions

Naltrexone Poa Pharma is indicated for the treatment of alcohol dependence and opioid dependence in adult patients. It helps reduce cravings and blocks the reinforcing effects of these substances, supporting abstinence and relapse prevention.

Naltrexone works by competitively binding to mu‑opioid receptors in the central nervous system, preventing activation by endogenous opioids or external opioid drugs. This blockade reduces the rewarding sensations associated with alcohol and opioid use, aiding in dependence management.

The specific dose and dosing schedule of Naltrexone Poa Pharma are determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and other clinical factors. Patients should follow the prescriber’s instructions precisely.

Safety data for Naltrexone Poa Pharma in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Naltrexone Poa Pharma shares the same mechanism as other opioid antagonists such as naloxone, but it is formulated for oral use and is primarily used for long‑term maintenance therapy in dependence, whereas naloxone is typically administered parenterally for acute overdose reversal.

Store Naltrexone Poa Pharma at room temperature, below 25 °C, in the original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain its stability.

Naltrexone Poa Pharma is taken orally, usually as a tablet or capsule, with or without food as directed by the prescriber. The exact administration instructions should be followed as provided on the prescription label.

Serious risks include hepatotoxicity, severe depression or suicidal ideation, and allergic reactions such as rash or anaphylaxis. Patients should be monitored regularly for liver function and mood changes, and any signs of an allergic response require immediate medical attention.

Naltrexone Poa Pharma should not be used by individuals currently receiving opioid analgesics, those with acute hepatitis or severe liver impairment, or anyone with a known hypersensitivity to naltrexone or any of the product’s excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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