Product image of Naltrexone Viatris (Naltrexone Hydrochloride) supplied by GNH India

Naltrexone Viatris

Active Ingredient:
Naltrexone Hydrochloride
Origin:
EU

Naltrexone Viatris (Naltrexone Hydrochloride)

Naltrexone, the active ingredient in Naltrexone Viatris, is an opioid antagonist presented as an oral tablet for systemic use. It is employed to help individuals with alcohol dependence and opioid dependence reduce cravings and prevent relapse, acting on the central nervous system to block opioid receptors.

GNH India supplies Naltrexone Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

  • Naltrexone is an opioid antagonist used in the management of substance dependence disorders.
  • Alcohol dependence: reduces the urge to drink and supports abstinence in individuals with alcohol use disorder.
  • Opioid dependence: blocks the effects of opioid agonists, helping prevent relapse in patients recovering from opioid addiction.
  • Substance dependence (general): assists in maintaining sobriety across various opioid‑related dependence conditions.

How It Works

  • Naltrexone acts as a competitive antagonist at mu‑opioid receptors in the central nervous system. By binding to these receptors without activating them, it blocks the effects of both endogenous opioids and exogenous opioid drugs, diminishing the rewarding and reinforcing properties that contribute to dependence and reducing cravings associated with alcohol and opioid use.

Side Effects

Naltrexone may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Hepatotoxicity (elevated liver enzymes or liver injury)
  • Severe depression or suicidal thoughts
  • Allergic reactions such as rash, itching, or anaphylaxis

Precautions & Warnings

  • When prescribing Naltrexone, clinicians should consider several safety precautions to minimize risk.
  • Liver function assessment: evaluate hepatic enzymes before initiating therapy.
  • Depression monitoring: watch for worsening mood or suicidal thoughts.
  • Avoid in acute opioid withdrawal: initiating treatment may precipitate severe withdrawal symptoms.
  • Renal impairment caution: adjust use in patients with significant kidney disease.
  • Hepatic impairment adjustment: dose may need modification in severe liver dysfunction.
  • Store at below 25°C: keep in the original packaging, protect from moisture.

Avoid Interactions

Naltrexone can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Opioid agonists (e.g., morphine, oxycodone): antagonism can precipitate acute withdrawal.
  • Opioid‑containing cough medicines: may cause loss of analgesia and withdrawal.
  • Buprenorphine: competitive antagonism may reduce its therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Antidepressants (especially SSRIs): may increase risk of depression or suicidal ideation.
  • Hepatotoxic drugs (e.g., isoniazid, methotrexate): combined use may elevate liver injury risk.
  • CYP2D6 inhibitors (e.g., fluoxetine): may alter naltrexone metabolism, requiring monitoring.

Frequently Asked Questions

Naltrexone Viatris is prescribed to help manage alcohol dependence and opioid dependence. By blocking opioid receptors, it reduces cravings and the rewarding effects of alcohol and opioids, supporting patients in maintaining abstinence as part of a comprehensive treatment program.

Naltrexone works by competitively binding to mu‑opioid receptors in the brain without activating them. This blocks both endogenous opioids and external opioid drugs from stimulating the receptors, thereby diminishing the pleasurable sensations and cravings associated with alcohol and opioid use.

The specific dose of Naltrexone Viatris is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for naltrexone during pregnancy and lactation are limited. It is generally classified as a drug of unknown risk, and use is only recommended if the potential benefits outweigh any possible risks to the fetus or infant. Consultation with a healthcare provider is essential.

To order Naltrexone Viatris, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

The primary alternative to naltrexone is naloxone, which is a short‑acting opioid antagonist used mainly for emergency overdose reversal. Naltrexone has a longer duration of action and is used for maintenance therapy in dependence, whereas naloxone provides rapid, temporary blockade and is not intended for long‑term treatment.

Naltrexone Viatris should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency throughout its shelf life.

Naltrexone Viatris is administered orally, typically as a tablet taken with water. The exact timing relative to meals or other medications should follow the prescribing clinician’s guidance to ensure optimal absorption and effectiveness.

Serious risks include hepatotoxicity, severe depression or suicidal thoughts, and allergic reactions such as rash or anaphylaxis. Patients should promptly report any signs of liver dysfunction, mood changes, or hypersensitivity to their healthcare provider.

Naltrexone Viatris is contraindicated in individuals with acute opioid withdrawal, those who are currently using opioid analgesics, and patients with known hypersensitivity to naltrexone or any of its excipients. Caution is also advised for patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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