Product image of Naltrexonhydrochloride Pch (Naltrexone Hydrochloride) supplied by GNH India

Naltrexonhydrochloride Pch

Active Ingredient:
Naltrexone Hydrochloride
Origin:
EU

Naltrexonhydrochloride Pch (Naltrexone Hydrochloride)

Naltrexone Hydrochloride, the active ingredient in Naltrexonhydrochloride Pch, is an opioid antagonist presented as an oral dosage form for oral use. It is employed in the management of alcohol dependence and opioid dependence, helping to reduce cravings and block the effects of opioids in adult patients.

GNH India supplies Naltrexonhydrochloride Pch as a licensed, GDP‑compliant international pharmaceutical supplier, sourcing the product from EU manufacturers and serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmachemie Bv

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Indications & Clinical Uses

Naltrexone Hydrochloride acts on the opioid receptor system and is indicated for conditions related to substance dependence.

  • Alcohol dependence: reduces cravings and supports abstinence in patients seeking to stop drinking.
  • Opioid dependence: blocks mu‑opioid receptors to prevent relapse after detoxification.
  • Prevention of opioid relapse: used as part of maintenance therapy to sustain opioid‑free status.

How It Works

  • Naltrexone Hydrochloride is a competitive antagonist at opioid receptors, primarily the mu‑opioid subtype. By binding to these receptors without activating them, it blocks the effects of both endogenous opioids and exogenous opioid agonists, thereby diminishing reinforcement, craving, and the physiological response associated with alcohol and opioid use.

Side Effects

Naltrexone Hydrochloride may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headed sensation.
  • Fatigue: feeling unusually tired.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe depression or suicidal thoughts: mood changes requiring immediate medical attention.
  • Allergic reactions: rash, itching, or swelling that may indicate hypersensitivity.

Precautions & Warnings

Before initiating therapy with Naltrexone Hydrochloride, several safety considerations should be observed.

  • Assess liver function: monitor hepatic enzymes prior to and during treatment.
  • Avoid in acute hepatitis: contraindicated in patients with severe liver disease.
  • Caution in renal impairment: dose may need adjustment in reduced kidney function.
  • Do not combine with opioid analgesics: may precipitate acute withdrawal.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Naltrexone Hydrochloride can interact with several medication classes, requiring careful management.

Major Interactions (Avoid)

  • Opioid analgesics: can cause sudden opioid withdrawal.
  • Disulfiram: may increase risk of hepatotoxicity.
  • Alcohol: can enhance central nervous system depression.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: additive sedation and respiratory depression.
  • Antidepressants (SSRIs): monitor for mood alterations.
  • CYP3A4 inhibitors: may raise naltrexone plasma concentrations.

Frequently Asked Questions

Naltrexonhydrochloride Pch contains naltrexone hydrochloride, which is prescribed to help manage alcohol dependence and opioid dependence. It works by reducing cravings and blocking the reinforcing effects of alcohol and opioids, supporting patients in maintaining abstinence.

Naltrexone hydrochloride is a competitive antagonist at mu‑opioid receptors. By occupying these receptors without activating them, it prevents both endogenous opioids and external opioid drugs from binding, thereby diminishing the rewarding and physiological effects associated with alcohol and opioid use.

The specific dose of naltrexone hydrochloride is determined by the prescribing clinician based on the individual patient's condition, treatment goals, and medical history. Healthcare professionals tailor the regimen to achieve optimal therapeutic benefit while monitoring safety.

Safety data for naltrexone hydrochloride in pregnancy and lactation are limited, and the product’s pregnancy category is not established. Clinicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Naltrexone differs from opioid agonist therapies such as methadone or buprenorphine because it blocks opioid receptors rather than activating them. This makes it useful for patients who prefer an antagonist approach and have completed detoxification, whereas agonist therapies provide substitution and may be chosen for ongoing maintenance.

Naltrexonhydrochloride Pch should be stored at ambient temperature below 25 °C. Keep the product in its original packaging, protect it from moisture, and avoid exposure to direct sunlight to maintain stability and potency.

The medication is supplied as an oral formulation intended for swallowing with water. Patients should follow the prescribing clinician’s instructions regarding timing, whether to take with or without food, and any necessary monitoring during therapy.

Serious risks include potential liver injury, severe depression or suicidal ideation, and hypersensitivity reactions such as rash or swelling. Patients should be monitored regularly for hepatic function and mood changes, and any signs of an allergic response require immediate medical attention.

Naltrexone is contraindicated in individuals with acute hepatitis or severe liver impairment, those currently dependent on opioids without prior detoxification, and patients with known hypersensitivity to the drug. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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