Product image of Namaxir (Methotrexate) supplied by GNH India

Namaxir

Active Ingredient:
Methotrexate
Origin:
EU

Namaxir (Methotrexate)

Methotrexate, the active ingredient in Namaxir, is an Antimetabolite presented as a solution for Subcutaneous use. It is employed to manage rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia and Crohn's disease in appropriate patients.

GNH India supplies Namaxir as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Methotrexate is used across several disease categories where immune modulation or anti‑proliferative effects are required.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: diminishes skin plaque formation and severity.
  • Acute lymphoblastic leukemia: interferes with malignant cell replication.
  • Crohn's disease: alleviates intestinal inflammation and promotes remission.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, blocking the conversion of dihydrofolate to tetrahydrofolate and thereby disrupting folate‑dependent synthesis of purines and pyrimidines. This impairs DNA, RNA and protein synthesis in rapidly dividing cells and also modulates inflammatory pathways, resulting in immunosuppressive and anti‑inflammatory effects.

Side Effects

Methotrexate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Fatigue: generalized tiredness.
  • Oral ulceration: sores in the mouth.
  • Elevated liver enzymes: transient hepatic enzyme rise.
  • Cytopenias: mild reduction in blood cell counts.

Serious or Rare Side Effects

  • Hepatotoxicity: severe liver injury requiring monitoring.
  • Pulmonary fibrosis: progressive lung scarring.
  • Severe infection: opportunistic infections due to immunosuppression.
  • Bone marrow failure: aplastic anemia.
  • Renal toxicity: impaired kidney function.

Precautions & Warnings

Methotrexate requires careful monitoring and specific safety measures.

  • Pregnancy contraindication: avoid use in pregnancy (Category X).
  • Liver monitoring: perform regular liver function tests.
  • Hematologic monitoring: check complete blood counts frequently.
  • Renal function: assess kidney function before and during therapy.
  • Concomitant drugs: avoid live vaccines and limit NSAID use.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Methotrexate interacts with several medicines that can alter its efficacy or safety.

Major Interactions (Avoid)

  • NSAIDs: increase risk of toxicity.
  • Penicillins: may enhance myelosuppression.
  • Sulfonamides: potentiate hematologic effects.
  • Live vaccines: risk of severe infection.
  • Alcohol: exacerbates liver injury.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase anticoagulant effect.
  • Proton pump inhibitors: can affect absorption.
  • Trimethoprim‑sulfamethoxazole: may increase myelosuppression.
  • Azathioprine: additive immunosuppression.
  • Vitamin supplements containing folic acid: may reduce efficacy.

Frequently Asked Questions

Namaxir contains methotrexate and is indicated for rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia and Crohn's disease, where it helps control inflammation or suppress abnormal cell growth.

Methotrexate blocks the enzyme dihydrofolate reductase, preventing folate metabolism needed for DNA synthesis. This limits rapid cell division and modulates immune pathways, providing anti‑inflammatory and immunosuppressive effects.

The dose of Namaxir is individualized by the prescribing clinician based on the specific indication, patient characteristics and response. Exact dosing regimens are determined by the treating physician.

Methotrexate is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to known fetal toxicity. It is also not recommended while breastfeeding because it can be excreted in milk.

To request Namaxir, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Methotrexate is a low‑cost, well‑studied antimetabolite that offers both anti‑inflammatory and anti‑proliferative actions. Compared with biologic agents, it has a broader range of indications but may require more laboratory monitoring for hepatic and hematologic safety.

Namaxir should be stored at 2‑8 °C, kept refrigerated, protected from light, and never frozen or shaken. Maintaining the cold chain preserves the stability of the injectable solution.

Namaxir is supplied as a subcutaneous injection solution. It is administered by a healthcare professional using aseptic technique, typically into the abdomen or thigh, according to the prescriber's instructions.

Serious risks include severe liver toxicity, pulmonary fibrosis, bone marrow failure leading to aplastic anemia, and life‑threatening infections. Patients should be monitored regularly for these complications.

Namaxir is contraindicated in pregnant women, individuals with severe liver or renal impairment, those with known hypersensitivity to methotrexate, and patients receiving live vaccines. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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