Product image of Nambrol Adulti (Flunisolide) supplied by GNH India

Nambrol Adulti

Active Ingredient:
Flunisolide
Origin:
EU

Nambrol Adulti (Flunisolide)

Flunisolide, the active ingredient in Nambrol Adulti, is a corticosteroid presented as an inhalation formulation for respiratory use. It is prescribed to reduce airway inflammation in patients with asthma and related respiratory conditions.

GNH India supplies Nambrol Adulti as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lanova Farmaceutici S.R.L.

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Indications & Clinical Uses

Flunisolide is a corticosteroid that reduces airway inflammation in respiratory disorders.

  • Asthma: provides maintenance therapy to control persistent symptoms and prevent exacerbations.
  • Chronic bronchial hyperresponsiveness: diminishes airway reactivity to triggers.
  • Allergic airway disease: alleviates inflammation associated with allergic triggers.

How It Works

  • Flunisolide binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses pro‑inflammatory cytokine production, inhibits activation of immune cells such as eosinophils and mast cells, and reduces edema of the airway mucosa, leading to improved airflow.

Side Effects

Inhaled flunisolide may cause a range of adverse reactions, most of which are related to local airway exposure.

Common Side Effects

  • Oral thrush: fungal infection of the mouth and throat.
  • Hoarseness or dysphonia: voice changes due to laryngeal irritation.
  • Cough or throat irritation: transient discomfort after inhalation.
  • Headache: mild to moderate intensity.
  • Sore throat: irritation of the oropharynx.

Serious or Rare Side Effects

  • Adrenal suppression: reduced endogenous cortisol production.
  • Pneumonia: increased susceptibility to lower respiratory infections.
  • Cataracts or glaucoma: ocular pressure changes with long‑term use.
  • Severe allergic reaction: anaphylaxis or angioedema.
  • Immunosuppression: heightened risk of systemic infections.

Precautions & Warnings

When prescribing inhaled flunisolide, clinicians should consider several safety measures.

  • Monitor growth in children: assess height regularly during long‑term therapy.
  • Assess for oral candidiasis: advise rinsing mouth after each use.
  • Avoid abrupt discontinuation: taper dose to prevent adrenal insufficiency.
  • Use a spacer device: reduces oropharyngeal deposition and side effects.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Flunisolide can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Ketoconazole: may increase systemic corticosteroid exposure.
  • Ritonavir: can raise flunisolide plasma levels.
  • Systemic corticosteroids: additive immunosuppressive effects.

Moderate Interactions (Monitor Closely)

  • Beta‑agonists: may mask worsening asthma symptoms.
  • Diuretics: potential for hypokalemia when combined with systemic steroids.
  • Anticholinergics: may affect inhalation technique and drug deposition.

Frequently Asked Questions

Nambrol Adulti contains flunisolide, an inhaled corticosteroid used to reduce airway inflammation in patients with asthma. It helps control persistent symptoms and lowers the risk of asthma attacks when used as part of a maintenance regimen prescribed by a healthcare professional.

Flunisolide binds to glucocorticoid receptors inside airway cells, altering gene expression to suppress inflammatory cytokines, inhibit immune‑cell activation, and reduce mucosal edema. This results in smoother airways and improved breathing for individuals with inflammatory respiratory conditions.

The specific dose of Nambrol Adulti is determined by the prescribing clinician based on the patient’s age, severity of asthma, and response to therapy. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety data for flunisolide in pregnancy and lactation are limited. Healthcare providers usually weigh the potential benefits against possible risks before prescribing it to pregnant or nursing individuals. Patients should discuss their specific situation with a qualified medical professional.

To request Nambrol Adulti, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nambrol Adulti (flunisolide) offers a potency profile similar to other medium‑strength inhaled corticosteroids such as budesonide or beclomethasone. Choice among agents often depends on device preference, dosing frequency, patient response, and formulary considerations rather than major differences in efficacy.

Store Nambrol Adulti at room temperature, below 25 °C. Keep the inhaler in its original packaging, protect it from moisture and direct sunlight, and ensure the mouthpiece remains clean to maintain drug stability.

Nambrol Adulti is delivered by inhalation using a metered‑dose inhaler or a compatible device. Patients should inhale slowly and deeply, hold their breath for a few seconds, and then exhale. Rinsing the mouth after each use helps reduce local side effects.

Serious risks, though uncommon, include adrenal suppression, severe allergic reactions such as anaphylaxis, and opportunistic infections like pneumonia. Patients should be educated to recognize symptoms such as unusual fatigue, severe shortness of breath, or swelling and seek medical attention promptly.

Nambrol Adulti is contraindicated in individuals with a known hypersensitivity to flunisolide or any component of the inhaler. It should also be avoided in patients with active, untreated fungal, bacterial, or viral infections of the respiratory tract unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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