Product image of Nano-Albumon (Human Serum Albumin) supplied by GNH India

Nano-Albumon

Active Ingredient:
Human Serum Albumin
Origin:
EU

Nano-Albumon (Human Serum Albumin)

Human Serum Albumin, the active ingredient in Nano-Albumon, is an albumin presented as a solution for injection for intravenous use. It is employed to treat hypoalbuminemia, volume depletion, severe burns and shock by expanding plasma volume in affected patients.

GNH India supplies Nano-Albumon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to global markets. Customers benefit from reliable cold‑chain logistics and responsive technical support.

Manufacturer / TM Owner

Medi-Radiopharma Kft.

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Indications & Clinical Uses

  • Nano-Albumon, a human serum albumin solution, acts as a plasma volume expander in conditions associated with low oncotic pressure, helping to restore circulatory homeostasis.
  • Hypoalbuminemia: restores plasma albumin levels and improves oncotic pressure.
  • Volume depletion: expands intravascular volume to support circulatory stability.
  • Severe burns: provides colloid support to counter fluid loss and edema.
  • Shock: increases circulating volume to enhance tissue perfusion during acute circulatory failure.
  • Post‑operative fluid management: assists in maintaining adequate plasma volume after major surgery.

How It Works

  • Human serum albumin is the most abundant plasma protein and contributes significantly to colloid osmotic pressure. Intravenous infusion of Nano-Albumon raises the circulating albumin concentration, thereby increasing plasma oncotic pressure. The elevated oncotic gradient draws water from the interstitial space into the vascular compartment, expanding intravascular volume, improving cardiac preload and tissue perfusion. This effect supports hemodynamic stability in patients with hypoalbuminemia, fluid loss or shock.

Side Effects

Adverse reactions to Nano-Albumon may vary in frequency and severity.

Common Side Effects

  • Fever: transient rise in body temperature after infusion.
  • Chills: shivering or feeling cold during or shortly after administration.
  • Headache: mild to moderate headache reported by some patients.
  • Nausea: occasional upset stomach or feeling of queasiness.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical intervention.
  • Volume overload: excessive fluid accumulation leading to pulmonary edema.
  • Hemolysis: destruction of red blood cells in rare cases.
  • Thrombosis: formation of blood clots in veins or arteries.

Precautions & Warnings

When using Nano-Albumon, clinicians should observe several precautionary measures to ensure patient safety.

  • Assess albumin levels: verify hypoalbuminemia before initiating therapy.
  • Monitor fluid balance: track input and output to avoid overload.
  • Evaluate cardiac function: use caution in patients with heart failure.
  • Screen for hypersensitivity: discontinue if signs of allergic reaction appear.
  • Adjust in renal impairment: consider reduced dosing in severe kidney disease.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Nano-Albumon may interact with other medicines, altering fluid status or hemodynamic responses.

Major Interactions (Avoid)

  • High‑dose loop diuretics: concurrent use can precipitate profound volume depletion.
  • Other colloid solutions: combined administration may cause excessive plasma volume and overload.
  • Vasopressor agents: may require dose adjustments due to altered vascular tone.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: monitor blood pressure for additive hypotensive effect.
  • Anticoagulants: albumin infusion can affect coagulation parameters; observe bleeding risk.
  • Radiographic contrast media: assess renal function as combined volume shifts may increase nephrotoxicity.

Frequently Asked Questions

Nano-Albumon is a sterile solution of human serum albumin administered intravenously to treat conditions that require plasma volume expansion. It is indicated for hypoalbuminemia, acute volume depletion, severe burns, and shock, where restoring oncotic pressure helps maintain circulatory stability and tissue perfusion.

Human serum albumin is the main protein responsible for maintaining colloid osmotic pressure in the blood. When infused, it raises the plasma albumin concentration, increasing oncotic pressure. This draws water from the interstitial space into the vascular compartment, expanding intravascular volume and supporting blood pressure and organ perfusion.

The prescribed dose of Nano-Albumon is determined by the treating physician based on the patient’s clinical condition, baseline albumin level, and required volume expansion. Dosing is individualized and may be expressed in grams or milliliters per kilogram of body weight, with adjustments made according to response and safety monitoring.

Safety data for Nano-Albumon in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order Nano-Albumon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including cold‑chain logistics if needed) and assists with import documentation.

Nano-Albumon, as a natural albumin solution, provides oncotic pressure similar to native plasma proteins, unlike synthetic colloids that may carry higher risks of coagulopathy or renal impairment. Compared with crystalloids, albumin achieves greater intravascular retention with smaller volumes, but it is more costly. Choice of therapy depends on clinical indication, patient status and cost considerations.

Nano-Albumon must be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Before use, inspect for particulate matter or discoloration and discard any product that appears compromised.

Nano-Albumon is administered by intravenous infusion, typically through a peripheral or central line. The infusion rate is set by the prescriber and may be adjusted based on the patient’s hemodynamic response and tolerance. Monitoring of vital signs, fluid balance and serum albumin levels is recommended during and after the infusion.

The most serious adverse events include anaphylactic or severe allergic reactions, volume overload leading to pulmonary edema, and rare occurrences of hemolysis or thrombosis. Prompt recognition and management of these reactions are essential, and patients should be closely monitored for signs of respiratory distress, sudden swelling, or changes in coagulation status.

Nano-Albumon is contraindicated in individuals with known hypersensitivity to human serum albumin or any excipients in the formulation. It should also be avoided in patients with uncontrolled heart failure, severe pulmonary edema, or active bleeding where additional volume expansion could worsen the condition. Clinical judgment is required for use in patients with renal impairment or other comorbidities.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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