Product image of Nanogam (Human Normal Immunoglobulin) supplied by GNH India

Nanogam

Active Ingredient:
Human Normal Immunoglobulin
Origin:
EU

Nanogam (Human Normal Immunoglobulin)

Human Normal Immunoglobulin, the active ingredient in Nanogam, is an immunoglobulin presented as a solution for injection for intravenous use. It replaces deficient IgG antibodies and is used in primary and secondary immunodeficiency diseases, immune thrombocytopenic purpura, and Kawasaki disease.

GNH India supplies Nanogam as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Prothya Biosolutions Netherlands B.V.

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Indications & Clinical Uses

Nanogam is an immunoglobulin replacement therapy used to address immune deficiencies and related disorders.

  • Primary immunodeficiency diseases: provides IgG replacement to reduce infection frequency and severity.
  • Secondary immunodeficiency: restores antibody levels compromised by disease or treatment.
  • Immune thrombocytopenic purpura (ITP): modulates immune response to increase platelet counts.
  • Kawasaki disease: used as adjunct therapy to lessen inflammation and prevent coronary artery complications.

How It Works

  • Nanogam supplies exogenous human IgG antibodies that bind to pathogens, toxins, and immune complexes, neutralizing them and facilitating clearance via Fc‑receptor mediated phagocytosis. The infused IgG also exerts immunomodulatory effects by interacting with B‑cell receptors and complement pathways, thereby providing passive immunity and helping to regulate abnormal immune responses.

Side Effects

Nanogam may cause a range of adverse reactions, most of which are related to the intravenous infusion process.

Common Side Effects

  • Infusion‑related reactions (e.g., chills, fever, flushing)
  • Headache
  • Nausea
  • Fatigue

Serious or Rare Side Effects

  • Anaphylaxis or severe allergic reaction
  • Aseptic meningitis
  • Acute renal failure
  • Thrombotic events (e.g., deep vein thrombosis)
  • Hemolysis
  • Severe hypotension

Precautions & Warnings

Before initiating Nanogam therapy, clinicians should consider several safety measures.

  • Baseline assessment: evaluate patient’s IgG levels and renal function.
  • Infusion monitoring: observe for signs of reaction and adjust rate as needed.
  • Pre‑medication: consider antihistamines or antipyretics to reduce infusion symptoms.
  • Contraindication check: avoid in patients with known IgA deficiency who have anti‑IgA antibodies.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Nanogam can interact with other therapies, requiring attention to avoid reduced efficacy or increased risk.

Major Interactions (Avoid)

  • Live vaccines: may diminish vaccine effectiveness.
  • Concurrent immunoglobulin products: risk of immunoglobulin overload.
  • Monoclonal antibodies targeting B cells: may heighten infection susceptibility.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may mask infusion‑related reactions.
  • Anticoagulants: potential for increased bleeding with IV administration.
  • Non‑live vaccines: possible altered immune response, monitor antibody titers.

Frequently Asked Questions

Nanogam is indicated for patients with primary or secondary immunodeficiency diseases, immune thrombocytopenic purpura (ITP), and Kawasaki disease. In these conditions, it provides exogenous IgG antibodies to help restore immune function and reduce disease‑related complications.

Human Normal Immunoglobulin in Nanogam supplies a broad spectrum of IgG antibodies that bind to pathogens and toxins, neutralizing them. It also modulates the immune system by interacting with Fc receptors, helping to regulate abnormal immune responses and providing passive immunity.

The dose of Nanogam is individualized. The prescribing clinician determines the appropriate amount and infusion rate based on the patient’s weight, IgG level, and clinical condition. Dosing regimens are not standardized and should follow the prescriber’s instructions.

Safety data for Nanogam in pregnancy and lactation are limited. The product’s pregnancy category is unknown, so clinicians must weigh potential benefits against risks. Use is generally considered only if clearly needed, and breastfeeding decisions should be made in consultation with a healthcare professional.

To order Nanogam, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details, and necessary import documentation.

Nanogam is a human normal immunoglobulin solution comparable to other IVIG products in providing IgG replacement. Differences may lie in manufacturing processes, concentration, and regulatory origin (EU). Clinicians choose a product based on availability, patient tolerance, and specific clinical guidelines.

Nanogam must be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. Do not use the product if it has been exposed to temperatures outside this range.

Nanogam is given as an intravenous infusion. The healthcare professional prepares the solution according to aseptic technique, selects an appropriate infusion set, and administers it over a period that may vary based on the patient’s tolerance and prescribed dose.

Serious risks include anaphylactic reactions, aseptic meningitis, acute renal failure, thrombotic events, hemolysis, and severe hypotension. Patients should be monitored closely during and after infusion, and any signs of these reactions require immediate medical attention.

Nanogam should not be used in individuals with a known severe IgA deficiency who have anti‑IgA antibodies, as they are at increased risk for anaphylaxis. It is also contraindicated in patients with a history of severe hypersensitivity to immunoglobulin products.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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