Product image of Nanohsa-Rotop (Human Serum Albumin) supplied by GNH India

Nanohsa-Rotop

Active Ingredient:
Human Serum Albumin
Origin:
EU

Nanohsa-Rotop (Human Serum Albumin)

Human Serum Albumin, the active ingredient in Nanohsa-Rotop, is a plasma protein presented as a sterile injectable solution for intravenous and subcutaneous use. It is employed to restore plasma oncotic pressure and expand intravascular volume in patients with hypovolemia, shock, severe burns, or hypoalbuminemia, particularly in critical care settings.

GNH India supplies Nanohsa-Rotop as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to EU GMP standards and provides cold‑chain logistics for safe delivery to healthcare facilities.

Manufacturer / TM Owner

Rotop Pharmaka Gmbh

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Indications & Clinical Uses

Nanohsa‑Rotop, a human serum albumin preparation, is used in clinical situations that require plasma volume expansion.

  • Hypovolemia: restores intravascular volume and improves tissue perfusion.
  • Shock: supports circulatory stability by increasing oncotic pressure.
  • Severe burns: aids fluid resuscitation and maintains plasma protein levels.
  • Hypoalbuminemia: replenishes deficient albumin to correct oncotic deficits.

How It Works

  • Human Serum Albumin acts as a natural plasma protein that generates oncotic pressure within the vascular compartment. By increasing colloid osmotic force, it draws water from the interstitial space into the bloodstream, thereby expanding intravascular volume and improving hemodynamic stability in patients with fluid loss or low albumin levels.

Side Effects

Adverse reactions may occur with any albumin infusion.

Common Side Effects

  • Fever: transient rise in body temperature following infusion.
  • Chills: sensation of cold or shivering during or after administration.
  • Hypotension: mild drop in blood pressure, especially with rapid infusion.
  • Injection site pain: discomfort at the site of intravenous or subcutaneous delivery.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical intervention.
  • Pulmonary edema: fluid accumulation in the lungs due to excessive volume expansion.
  • Severe hypertension: marked increase in blood pressure that may need urgent treatment.

Precautions & Warnings

Special considerations are required when using Nanohsa‑Rotop.

  • Renal impairment: monitor fluid balance and renal function closely.
  • Cardiac failure: use cautiously to avoid fluid overload.
  • Pregnancy: safety not established; weigh potential benefits against risks.
  • Allergy: assess for known hypersensitivity to human albumin before administration.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions should be evaluated before therapy.

Major Interactions (Avoid)

  • Concurrent use with high‑dose diuretics in hypovolemic patients may cause severe hypotension.
  • Co‑administration with other volume expanders can lead to fluid overload.

Moderate Interactions (Monitor Closely)

  • Nephrotoxic agents: monitor renal function during combined therapy.
  • Anticoagulants: observe for altered bleeding risk.
  • Vasopressors: dose adjustments may be needed based on hemodynamic response.

Frequently Asked Questions

Nanohsa‑Rotop is a sterile human serum albumin solution used as a plasma volume expander. It helps restore intravascular volume and oncotic pressure in conditions such as hypovolemia, circulatory shock, severe burns, and hypoalbuminemia, supporting tissue perfusion and hemodynamic stability.

Human Serum Albumin increases the colloid osmotic pressure within the bloodstream. By providing exogenous albumin, it draws fluid from the interstitial space into the vascular compartment, expanding plasma volume and improving circulatory function in patients with fluid deficits or low albumin levels.

The prescribed dose of Nanohsa‑Rotop is individualized by the treating clinician based on the patient’s clinical status, degree of volume loss, albumin concentration, and target hemodynamic goals. No fixed regimen is provided; dosing decisions are made at the point of care.

Safety data for Nanohsa‑Rotop during pregnancy and lactation are limited. The product should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the prescribing physician.

To order Nanohsa‑Rotop, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Nanohsa‑Rotop provides a natural colloid solution, offering higher oncotic pressure than crystalloids such as saline and fewer renal side effects than some synthetic colloids. Compared with synthetic options, albumin carries a lower risk of coagulopathy but is more expensive and requires cold‑chain handling.

Nanohsa‑Rotop must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the product to maintain stability and sterility.

Nanohsa‑Rotop is administered by intravenous or subcutaneous infusion under aseptic conditions. The infusion rate is determined by the clinician, and the solution should be given through a suitable filter to ensure particle removal before administration.

The most serious adverse events include anaphylactic reactions, pulmonary edema due to fluid overload, and severe hypertension. Immediate medical attention is required if any signs of these reactions appear during or after infusion.

Nanohsa‑Rotop is contraindicated in patients with known hypersensitivity to human serum albumin, severe uncontrolled heart failure, or uncontrolled hypertension. Caution is also advised for individuals with renal impairment or those at high risk of fluid overload.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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