Product image of Nanotop (Human Serum Albumin) supplied by GNH India

Nanotop

Active Ingredient:
Human Serum Albumin
Origin:
EU

Nanotop (Human Serum Albumin)

Human Serum Albumin, the active ingredient in Nanotop, is a plasma protein preparation presented as a solution for subcutaneous use. It is used to restore plasma volume and maintain oncotic pressure in patients with hypoalbuminemia or acute fluid loss.

GNH India supplies Nanotop as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Manufacturer / TM Owner

Rotop Pharmaka Gmbh

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Indications & Clinical Uses

Nanotop contains human serum albumin and is employed in clinical situations that require plasma volume support or correction of low albumin levels.

  • Hypoalbuminemia: restores oncotic pressure and improves fluid balance.
  • Acute burns or trauma: provides volume expansion when large fluid shifts occur.
  • Major surgery: supports intravascular volume during peri‑operative management.
  • Liver disease with ascites: helps maintain plasma oncotic pressure and reduces edema.

How It Works

  • Human serum albumin acts as a natural plasma colloid, increasing oncotic pressure and thereby retaining water within the vascular compartment. It also binds endogenous substances such as hormones, fatty acids, and drugs, contributing to transport and distribution while supporting overall plasma protein homeostasis.

Side Effects

Human serum albumin may be associated with a range of adverse reactions.

Common Side Effects

  • Fever or chills
  • Local injection site reactions (pain, erythema)
  • Headache
  • Nausea or vomiting
  • Hypotension
  • Transient rash

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction
  • Volume overload leading to pulmonary edema
  • Thromboembolic events
  • Hemolysis
  • Transmission of infectious agents (theoretical risk)
  • Severe electrolyte disturbances

Precautions & Warnings

When using Nanotop, clinicians should observe several safety measures.

  • Assess baseline albumin levels: determine need for replacement.
  • Monitor fluid status: avoid overload in patients with cardiac or renal impairment.
  • Use cautiously in heart failure: risk of volume overload.
  • Avoid in known hypersensitivity to human serum albumin.
  • Employ aseptic technique during subcutaneous administration.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Human serum albumin can interact with other agents affecting fluid balance or protein binding.

Major Interactions (Avoid)

  • Concurrent use with other colloid volume expanders may cause excessive plasma volume.
  • Simultaneous administration with high‑dose diuretics can precipitate severe hypovolemia.

Moderate Interactions (Monitor Closely)

  • Co‑administration with vasopressors may alter hemodynamic response.
  • Drugs highly bound to albumin (e.g., warfarin, phenytoin) may have altered free concentrations.
  • Nephrotoxic agents combined with volume expansion require renal function monitoring.

Frequently Asked Questions

Nanotop is a human serum albumin solution administered subcutaneously to restore plasma oncotic pressure and expand intravascular volume in conditions such as hypoalbuminemia, severe burns, major surgery, and liver disease with fluid shifts.

Human serum albumin increases plasma oncotic pressure, which helps retain water inside blood vessels, thereby expanding circulating volume. It also serves as a carrier protein, binding hormones, fatty acids, and certain drugs, supporting their transport and distribution.

The dose of Nanotop is individualized by the prescribing clinician based on the patient’s albumin level, clinical condition, and desired volume expansion. Exact dosing regimens are determined at the point of care.

Safety data for human serum albumin in pregnancy and lactation are limited. Use is generally reserved for situations where the potential benefit outweighs any theoretical risk, and it should be prescribed by a qualified healthcare professional.

To order Nanotop, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Nanotop (human serum albumin) is a natural plasma protein, offering oncotic pressure support without the risk of electrolyte imbalance seen with crystalloid solutions. Compared with synthetic colloids, it has a well‑characterized safety profile and lower incidence of coagulopathy, though cost and availability may differ.

Nanotop should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any product that appears discolored or contains particles.

Nanotop is given by subcutaneous injection using aseptic technique. The injection site should be rotated, and the volume administered per site should follow the prescriber’s instructions to minimize local reactions.

Serious risks include anaphylactic reactions, volume overload leading to pulmonary edema, and rare thromboembolic events. Patients should be monitored closely for signs of hypersensitivity, respiratory distress, or sudden cardiovascular changes during and after administration.

Nanotop is contraindicated in individuals with known hypersensitivity to human serum albumin or any component of the formulation. Caution is advised in patients with severe heart failure, uncontrolled hypertension, or active pulmonary edema, where additional volume may be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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