Product image of Naphthyzinum (Naphazoline Nitrate) supplied by GNH India

Naphthyzinum

Active Ingredient:
Naphazoline Nitrate
Origin:
EU

Naphthyzinum (Naphazoline Nitrate)

Naphazoline nitrate, the active ingredient in Naphthyzinum, is an imidazoline sympathomimetic (vasoconstrictor) presented as a nasal spray for nasal administration. It relieves nasal congestion associated with rhinitis and other upper‑respiratory conditions in adults and children.
GNH India supplies Naphthyzinum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ag Farm Baltic

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Indications & Clinical Uses

Naphthyzinum is a nasal decongestant that acts on the upper‑respiratory tract to reduce swelling of the nasal mucosa.

  • Nasal congestion: provides rapid relief of blocked nasal passages.
  • Allergic rhinitis: diminishes swelling and improves airflow during allergic episodes.
  • Non‑allergic rhinitis: eases congestion caused by irritants or vasomotor changes.

How It Works

  • Naphazoline nitrate acts as an alpha‑adrenergic receptor agonist on the smooth muscle of nasal blood vessels. Stimulation of these receptors causes vasoconstriction, which reduces blood flow to the nasal mucosa, decreasing edema and opening the airway for easier breathing.

Side Effects

Naphthyzinum may cause local and systemic reactions after nasal use.

Common Side Effects

  • Burning or stinging sensation in the nose.
  • Nasal dryness or irritation.
  • Sneezing shortly after application.
  • Mild headache.
  • Transient increase in blood pressure.

Serious or Rare Side Effects

  • Persistent nasal congestion (rebound effect) after prolonged use.
  • Severe hypertension.
  • Cardiac arrhythmias.
  • Allergic reactions such as rash, itching, or swelling of the face.
  • Nasal ulceration or tissue necrosis with excessive dosing.

Precautions & Warnings

Before using Naphthyzinum, consider the following safety measures.

  • Cardiovascular disease: avoid if you have uncontrolled hypertension or heart disease.
  • Glaucoma: use with caution, especially angle‑closure type.
  • Diabetes: monitor blood pressure as vasoconstriction may affect glycemic control.
  • Pregnancy and breastfeeding: safety not established; consult a healthcare professional.
  • Children under 6 years: not recommended without medical advice.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Naphthyzinum can interact with other medications that affect vascular tone or blood pressure.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may cause excessive hypertensive response.
  • Other nasal decongestants (e.g., oxymetazoline): risk of severe vasoconstriction and rebound congestion.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs (beta‑blockers, ACE inhibitors): may blunt blood‑pressure‑lowering effect.
  • Tricyclic antidepressants: possible additive increase in blood pressure.
  • Cocaine or sympathomimetic agents: heightened risk of cardiovascular adverse events.

Frequently Asked Questions

Naphthyzinum is indicated for the temporary relief of nasal congestion associated with allergic and non‑allergic rhinitis. It works by narrowing the blood vessels in the nasal passages, which reduces swelling and improves airflow.

Naphazoline nitrate is an alpha‑adrenergic agonist. When applied to the nasal mucosa it stimulates alpha receptors on vascular smooth muscle, causing vasoconstriction. This reduces blood flow to the swollen tissue, decreasing edema and opening the airway.

The appropriate dose of Naphthyzinum is determined by a qualified prescriber based on the patient’s age, severity of symptoms, and clinical response. Users should follow the specific instructions provided on the product label or by their healthcare professional.

Safety data for naphazoline nitrate in pregnancy and lactation are limited. It is classified as a category where the risk cannot be ruled out, so pregnant or nursing women should consult their physician before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Naphthyzinum contains naphazoline nitrate, an imidazoline sympathomimetic, whereas many alternatives such as oxymetazoline belong to the imidazoline class as well. Both provide rapid vasoconstriction, but differences in potency, duration of action and side‑effect profiles may influence clinician choice.

Store Naphthyzinum at temperatures below 25 °C in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing to maintain product stability.

Naphthyzinum is applied intranasally as a spray. The patient should tilt the head slightly forward, insert the nozzle into one nostril, and spray the recommended amount while breathing in gently. The process is repeated in the other nostril if directed by the prescriber.

Serious risks include rebound nasal congestion after prolonged use, severe hypertension, cardiac arrhythmias, and rare allergic reactions such as facial swelling or rash. Users should discontinue the product and seek medical attention if any of these events occur.

Naphthyzinum should be avoided in individuals with uncontrolled hypertension, severe cardiovascular disease, narrow‑angle glaucoma, or known hypersensitivity to naphazoline nitrate. Children under six years of age should not use it without explicit medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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