Product image of Naprius (Naproxen) supplied by GNH India

Naprius

Active Ingredient:
Naproxen
Origin:
EU

Naprius (Naproxen)

Naproxen, the active ingredient in Naprius, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for oral use. It is employed to relieve pain, reduce inflammation, and lower fever in adults experiencing conditions such as arthritis, dysmenorrhea, and other musculoskeletal discomforts.

GNH India supplies Naprius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and providing reliable sourcing for healthcare providers across multiple regions, including Europe, Asia and Africa.

Manufacturer / TM Owner

Aesculapius Farmaceutici S.R.L.

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Indications & Clinical Uses

Naproxen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Pain: Provides symptomatic relief of mild to moderate pain.
  • Inflammation: Decreases inflammatory response in conditions such as osteoarthritis.
  • Arthritis: Alleviates joint pain and swelling associated with rheumatoid and osteoarthritis.
  • Dysmenorrhea: Relieves menstrual cramps and associated discomfort.

How It Works

  • Naproxen reversibly inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, leading to reduced synthesis of prostaglandins that mediate inflammation, pain, and fever. This inhibition underlies its analgesic, anti‑inflammatory, and antipyretic actions while preserving platelet function to a greater extent than selective COX‑2 inhibitors.

Side Effects

Common Side Effects

  • Gastrointestinal discomfort such as nausea or dyspepsia.
  • Headache.
  • Dizziness.
  • Mild skin rash.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Acute renal failure or worsening kidney function.
  • Severe hypersensitivity reactions, including Stevens‑Johnson syndrome.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess renal function: monitor in patients with existing kidney disease.
  • Evaluate gastrointestinal risk: avoid in individuals with a history of ulcer or bleeding.
  • Consider cardiovascular risk: use cautiously in patients with heart disease.
  • Avoid in known hypersensitivity to NSAIDs or aspirin.
  • Use the lowest effective dose for the shortest duration needed.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Naproxen may interact with several drug classes. Major Interactions (Avoid):

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal and renal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may reduce renal function.
  • Diuretics: potential for renal impairment.
  • Lithium: may increase serum lithium levels.

Frequently Asked Questions

Naprius contains naproxen, an NSAID indicated for the relief of mild to moderate pain, reduction of inflammation, and fever control. It is commonly prescribed for conditions such as osteoarthritis, rheumatoid arthritis, musculoskeletal pain, and dysmenorrhea.

Naproxen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. Lower prostaglandin levels reduce the inflammatory response, diminish pain signaling, and lower body temperature when fever is present.

The appropriate dose of Naprius is determined by the prescribing healthcare professional based on the individual’s condition, age, weight, and response to therapy. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety of naproxen during pregnancy and lactation depends on the trimester and clinical circumstances. It is generally avoided in the third trimester and used only if the benefit outweighs the risk. Breastfeeding mothers should consult their physician, as naproxen can be excreted in milk.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Naprius (naproxen) has a longer half‑life than ibuprofen, allowing less frequent dosing for some patients. Compared with selective COX‑2 inhibitors, naproxen offers a broader anti‑inflammatory effect but may carry a higher risk of gastrointestinal irritation. Choice of NSAID should be individualized based on efficacy, safety profile, and patient comorbidities.

Naprius should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight, and excessive heat to maintain stability and potency.

Naprius is taken orally, usually with a full glass of water. It can be taken with or without food, though taking it with food may reduce gastrointestinal discomfort. Patients should swallow tablets whole and not crush or chew them unless instructed otherwise.

Serious risks include gastrointestinal ulceration or bleeding, acute kidney injury, and severe hypersensitivity reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should seek immediate medical attention if they experience black stools, severe abdominal pain, sudden swelling, or skin rash.

Naprius should be avoided in individuals with known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe heart failure, and in the third trimester of pregnancy. It is also contraindicated in patients with significant renal impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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