Product image of Naprosyn (Naproxen) supplied by GNH India

Naprosyn

Active Ingredient:
Naproxen
Origin:
EU

Naprosyn (Naproxen)

Naproxen, the active ingredient in Naprosyn, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a rectal suppository for local administration. It provides analgesic, anti‑inflammatory and antipyretic effects, helping to relieve pain, reduce swelling and lower fever in adults suffering from osteoarthritis, rheumatoid arthritis, dysmenorrhea and other inflammatory conditions.

GNH India supplies Naprosyn as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. All batches are manufactured under EU GMP guidelines and undergo rigorous quality testing before distribution.

Manufacturer / TM Owner

Recordati Industria Chimica E Farmaceutica S.P.A.

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Indications & Clinical Uses

Naprosyn (naproxen) is an NSAID that reduces inflammation and pain in musculoskeletal and gynecologic conditions.

  • Osteoarthritis: alleviates joint pain and improves mobility.
  • Rheumatoid arthritis: reduces joint inflammation and stiffness.
  • Dysmenorrhea: eases menstrual cramps and associated discomfort.
  • Acute pain: provides short‑term relief of moderate pain such as dental or postoperative pain.
  • Fever: lowers elevated body temperature in febrile states.

How It Works

  • Naproxen inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at the site of tissue injury.

Side Effects

Common Side Effects

  • Gastrointestinal upset: mild stomach discomfort or indigestion.
  • Nausea: feeling of queasiness after administration.
  • Headache: transient head pain.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding: potentially severe stomach or intestinal lesions.
  • Cardiovascular thrombotic events: increased risk of heart attack or stroke.
  • Renal impairment: reduced kidney function or acute kidney injury.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before using Naprosyn, consider the following precautions:

  • Assess renal function: evaluate kidney status prior to initiation.
  • Monitor gastrointestinal risk: avoid in patients with a history of ulcers or bleeding.
  • Evaluate cardiovascular risk: use cautiously in individuals with heart disease.
  • Use during pregnancy: avoid unless clearly needed and discuss with a healthcare professional.
  • Store at room temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Naprosyn can interact with other medicines. Review the following interactions:

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • SSRIs (e.g., fluoxetine): heightened bleeding risk.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in renal clearance.
  • Corticosteroids: enhanced risk of gastrointestinal ulceration.

Frequently Asked Questions

Naprosyn contains naproxen and is indicated for the relief of mild to moderate pain, reduction of inflammation, and lowering of fever. It is commonly prescribed for conditions such as osteoarthritis, rheumatoid arthritis, dysmenorrhea, and other inflammatory disorders where a rectal suppository formulation is appropriate.

Naproxen works by blocking the cyclooxygenase (COX) enzymes, COX‑1 and COX‑2, which are essential for the production of prostaglandins. By reducing prostaglandin synthesis, naproxen diminishes the inflammatory response, alleviates pain signals, and lowers body temperature during fever.

The dosage of Naprosyn is individualized by the prescribing clinician based on the patient’s condition, severity of symptoms, and overall health status. Healthcare professionals determine the appropriate strength, frequency, and duration of therapy according to current clinical guidelines.

Safety data for naproxen during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider after a thorough risk‑benefit assessment.

To place an order, submit an enquiry on the Naprosyn product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Both naproxen (Naprosyn) and ibuprofen belong to the NSAID class and share similar mechanisms of COX inhibition. Naproxen generally has a longer half‑life, allowing less frequent dosing, while ibuprofen may have a quicker onset. Safety profiles are comparable, but individual patient factors such as gastrointestinal tolerance and cardiovascular risk influence the choice between them.

Naprosyn suppositories should be stored at room temperature, below 25 °C, in their original packaging to protect them from moisture and direct sunlight. Keep the product out of reach of children and avoid storing in areas with high humidity or extreme heat.

Naprosyn is supplied as a rectal suppository. The patient should lie on their side with the lower leg drawn toward the abdomen, gently insert the suppository into the rectum, and remain lying down for a few minutes to ensure proper absorption. Hand washing before and after insertion is recommended.

Serious risks include gastrointestinal ulceration or bleeding, cardiovascular events such as heart attack or stroke, acute kidney injury, severe skin reactions like Stevens‑Johnson syndrome, and liver dysfunction. Patients should be educated to seek immediate medical attention if they experience symptoms such as severe abdominal pain, black stools, sudden swelling, or rash.

Naprosyn should be avoided in individuals with known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe heart failure, uncontrolled hypertension, and in patients who have had a recent coronary artery bypass graft. It is also contraindicated in those taking certain anticoagulants without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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