Product image of Naprosyne Enteric Coated (Naproxen) supplied by GNH India

Naprosyne Enteric Coated

Active Ingredient:
Naproxen
Origin:
EU

Naprosyne Enteric Coated (Naproxen)

Naproxen, the active ingredient in Naprosyne Enteric Coated, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an enteric coated tablet for oral use. It provides analgesic, anti‑inflammatory and antipyretic effects for adults experiencing pain, arthritis, dysmenorrhea and other inflammatory conditions.

GNH India supplies Naprosyne Enteric Coated as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution channels that meet EU regulatory standards. The product is sourced from EU‑approved manufacturers and shipped under controlled conditions to ensure product integrity.

Manufacturer / TM Owner

Atnahs Pharma Netherlands B.V.

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Indications & Clinical Uses

Naproxen, an NSAID, is used to manage conditions involving pain and inflammation.

  • Pain: Reduces mild to moderate pain associated with musculoskeletal disorders, dental procedures, or injury.
  • Inflammation: Decreases swelling and redness in acute inflammatory states such as sprains or bursitis.
  • Arthritis: Alleviates joint pain and stiffness in osteoarthritis and rheumatoid arthritis.
  • Dysmenorrhea: Relieves menstrual cramps and associated discomfort.

How It Works

  • Naproxen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at the site of tissue injury.

Side Effects

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate tension‑type headache.
  • Dizziness: transient light‑headedness or vertigo.
  • Rash: mild skin erythema or itching.
  • Elevated liver enzymes: transient increase in hepatic transaminases.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Cardiovascular events: myocardial infarction or stroke, especially with long‑term use.
  • Renal impairment: acute kidney injury or worsening of chronic kidney disease.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatotoxicity: significant liver injury with jaundice.
  • Anaphylaxis: rare but potentially life‑threatening allergic reaction.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
  • Evaluate cardiovascular profile: use cautiously in patients with heart disease or stroke risk.
  • Monitor renal function: avoid in severe renal impairment or dehydration.
  • Check hepatic status: use with caution in liver disease.
  • Review concomitant medications: avoid combinations that increase bleeding risk.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Naproxen may interact with several drug classes; monitoring is essential.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • SSRIs or SNRIs: heightened bleeding tendency.
  • Lithium: naproxen may raise lithium serum levels.
  • ACE inhibitors or ARBs: may reduce renal function.

Moderate Interactions (Monitor Closely)

  • Diuretics: potential reduction in antihypertensive effect.
  • Methotrexate: naproxen can decrease clearance, raising toxicity risk.
  • Digoxin: possible increase in serum concentrations.
  • Oral hypoglycemics: may enhance hypoglycemic effect.
  • Corticosteroids: combined use raises ulcer risk.

Frequently Asked Questions

Naprosyne Enteric Coated contains naproxen, an NSAID indicated for the relief of mild to moderate pain, reduction of inflammation, and fever. It is commonly prescribed for conditions such as osteoarthritis, rheumatoid arthritis, acute musculoskeletal pain, and dysmenorrhea.

Naproxen works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it reduces inflammation, pain signaling, and fever responses at the site of injury.

The specific dose of Naprosyne Enteric Coated is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of naproxen in pregnancy and lactation has not been definitively established. It is generally advised to avoid NSAIDs, including naproxen, during the third trimester of pregnancy. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Naprosyne (naproxen) has a longer half‑life than many NSAIDs such as ibuprofen, allowing for less frequent dosing. Its efficacy in pain and inflammation is comparable, but the risk profile for gastrointestinal and cardiovascular events is similar to other non‑selective NSAIDs. Choice of NSAID should be individualized based on patient risk factors.

Store Naprosyne Enteric Coated tablets at ambient temperature, below 25 °C, in the original packaging. Keep the container tightly closed, protect from moisture, heat, and direct sunlight to maintain tablet integrity.

The enteric‑coated tablets are intended for oral administration. Swallow the tablet whole with a full glass of water, preferably after a meal or with food to reduce gastrointestinal irritation. Do not crush, chew, or split the tablet, as this may compromise the enteric coating.

Serious risks include gastrointestinal bleeding or ulceration, cardiovascular events such as heart attack or stroke, renal impairment, and severe skin reactions like Stevens‑Johnson syndrome. Patients should be monitored for signs of bleeding, chest pain, sudden kidney dysfunction, or rash, and seek medical attention promptly if they occur.

Individuals with a known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulceration, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment should not use Naprosyne. Pregnant women in the third trimester and patients on anticoagulant therapy should also avoid it unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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