Naproxen Accord-Uk (Naproxen)

Naproxen is an NSAID that reduces pain and inflammation across several musculoskeletal and gynecologic conditions.

• Pain: provides analgesic relief for mild to moderate acute pain.
• Inflammation: reduces inflammatory response in soft tissues.
• Arthritis: alleviates joint pain and swelling associated with osteoarthritis and rheumatoid arthritis.
• Musculoskeletal disorders: eases discomfort from strains, sprains and back pain.
• Dysmenorrhea: helps control menstrual cramps.

• Naproxen reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels diminish peripheral sensitization and inflammatory mediator release, resulting in reduced pain perception and inflammation.

Adverse reactions may occur with naproxen use and are categorized by frequency and severity.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia, abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness: transient episodes.
• Rash: mild skin irritation.
• Elevated blood pressure: modest increase in some patients.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Renal impairment: reduced kidney function.
• Hepatotoxicity: elevated liver enzymes.
• Cardiovascular events: increased risk of thrombotic events.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Patients should be aware of specific safety considerations before using naproxen.

• Gastrointestinal risk: avoid use in patients with active ulcers or a history of GI bleeding.
• Cardiovascular caution: use cautiously in individuals with hypertension or heart disease.
• Renal monitoring: assess kidney function in patients with pre‑existing renal impairment.
• Hepatic function: monitor liver enzymes if liver disease is present.
• Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Naproxen may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding risk.
• Other NSAIDs or COX‑2 inhibitors: additive toxicity to GI tract and kidneys.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce antihypertensive effect and affect renal function.
• Diuretics: potential for reduced diuretic efficacy and renal impairment.
• Lithium: naproxen can increase lithium serum concentrations.