Naproxen-E Viatris (Naproxen)

Naproxen is an NSAID that reduces inflammation and pain in several musculoskeletal and gynecologic conditions.

• Mild to moderate pain: provides analgesic relief for acute and chronic pain states.
• Osteoarthritis: decreases joint inflammation and improves functional mobility.
• Rheumatoid arthritis: helps control inflammatory activity and joint swelling.
• Musculoskeletal pain: alleviates strain‑related discomfort and inflammation.
• Dysmenorrhea: reduces menstrual cramps and associated pelvic pain.

• Naproxen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, pain signaling, and fever generation at the site of tissue injury.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Elevated blood pressure.
• Skin rash or mild itching.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Renal impairment or acute kidney injury.
• Hepatotoxicity: elevated liver enzymes.
• Cardiovascular events: myocardial infarction or stroke.
• Severe hypersensitivity reactions such as Stevens‑Johnson syndrome.

Before initiating therapy, consider the following safety measures.

• Assess renal function: avoid use in patients with severe renal impairment.
• Evaluate hepatic status: monitor liver enzymes in patients with existing liver disease.
• Review cardiovascular risk: use cautiously in individuals with a history of heart disease.
• Check for gastrointestinal ulcer history: consider gastro‑protective agents if needed.
• Avoid use in late pregnancy: discuss alternatives with the prescriber.
• Store below 25°C: keep in the original pack, protect from moisture.

Naproxen may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding risk.
• Other NSAIDs or COX‑2 inhibitors: additive renal and gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
• Diuretics: may enhance renal impairment.
• Lithium: naproxen can raise lithium serum concentrations.
• Methotrexate: reduced clearance leading to toxicity.
• Corticosteroids: increased risk of gastrointestinal ulceration.