Product image of Naproxen/Esomeprazol Abdi (Esomeprazole, Naproxen) supplied by GNH India

Naproxen/Esomeprazol Abdi

Active Ingredient:
Esomeprazole, Naproxen
Origin:
EU

Naproxen/Esomeprazol Abdi (Esomeprazole, Naproxen)

Naproxen and Esomeprazole, the active ingredients in Naproxen/Esomeprazol Abdi, are an NSAID and a proton‑pump inhibitor presented as an oral combination tablet for oral use. The pair provides analgesic, anti‑inflammatory and gastro‑protective effects for adults with painful musculoskeletal conditions and for those at risk of NSAID‑induced ulcers.

GNH India supplies Naproxen/Esomeprazol Abdi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Abdi Farma Gmbh

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Indications & Clinical Uses

Naproxen/Esomeprazol Abdi acts on inflammatory and pain pathways as well as gastric acid secretion, making it suitable for several related conditions.

  • Osteoarthritis: reduces joint pain and inflammation, improving mobility.
  • Rheumatoid arthritis: alleviates systemic inflammation and joint discomfort.
  • Acute pain: provides rapid analgesia for musculoskeletal injuries.
  • Prevention of NSAID‑induced gastric ulcers: protects the stomach lining while NSAID therapy is required.

How It Works

  • Naproxen non‑selectively inhibits cyclo‑oxygenase‑1 and cyclo‑oxygenase‑2, decreasing prostaglandin synthesis and thereby reducing pain, inflammation and fever. Esomeprazole irreversibly binds to the gastric H+/K+‑ATPase (proton pump) in parietal cells, suppressing acid secretion and promoting mucosal protection. The combined effect delivers analgesia while minimizing gastric irritation associated with NSAID use.

Side Effects

Common Side Effects

  • Dyspepsia: mild stomach discomfort or heartburn.
  • Headache: transient cranial pain.
  • Dizziness: occasional light‑headedness.
  • Diarrhea: loose stools.
  • Nausea: feeling of sickness.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: visible blood in stool or vomiting blood.
  • Peptic ulcer perforation: severe abdominal pain requiring emergency care.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Liver enzyme elevation: abnormal liver function tests.
  • Acute kidney injury: reduced urine output or swelling.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.

Precautions & Warnings

Before prescribing Naproxen/Esomeprazol Abdi, clinicians should consider several safety factors.

  • Assess renal function: avoid or adjust in severe renal impairment.
  • Review gastrointestinal history: contraindicated in active peptic ulcer disease.
  • Evaluate cardiovascular risk: NSAIDs may increase thrombotic events.
  • Avoid concomitant anticoagulants: heightened bleeding risk.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Naproxen/Esomeprazol Abdi can interact with several drug classes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Corticosteroids: heightened ulcer risk.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors: possible bleeding increase.
  • Diuretics or ACE inhibitors: may affect renal function.
  • Lithium: elevated serum lithium levels.

Frequently Asked Questions

Naproxen/Esomeprazol Abdi is prescribed to relieve pain and inflammation in osteoarthritis and rheumatoid arthritis, to treat acute musculoskeletal pain, and to prevent gastric ulcers that can occur when an NSAID like naproxen is used alone.

Naproxen blocks cyclo‑oxygenase enzymes, lowering prostaglandin production and thus reducing pain and inflammation. Esomeprazole permanently deactivates the gastric proton pump, decreasing acid secretion and protecting the stomach lining from irritation caused by the NSAID.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s condition, age, renal function and other medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data are limited. Naproxen may affect fetal cardiovascular development, and esomeprazole crosses into breast milk in small amounts. The product should only be used during pregnancy or lactation if the potential benefit outweighs the risk and after consulting a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The combination adds esomeprazole, a proton‑pump inhibitor, which reduces the risk of stomach ulcers and bleeding that can occur with naproxen alone. Efficacy for pain relief remains comparable, while gastrointestinal safety is improved in patients at risk.

Store the tablets at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep out of reach of children and do not use after the expiration date.

The product is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can help reduce mild stomach discomfort. Swallow the tablet whole; do not crush or chew.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions such as anaphylaxis, liver enzyme abnormalities, acute kidney injury, and cardiovascular events like heart attack or stroke, especially in patients with existing risk factors.

Patients with active peptic ulcer disease, severe renal or hepatic impairment, known hypersensitivity to naproxen, esomeprazole or any component of the formulation, and those taking anticoagulants without close monitoring should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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